>Several Other Sizes Are Also Available. Please Inquire. Default Size: 200ugUpdated Date: Stock Protein updated on 20171228Research areas: OthersTarget / Protein: Cr1lBiologically active: Not TestedExpression system: E.coliSpecies of origin: Mus musculus (Mouse)Delivery time: 3-7 business daysUniprot ID: Q64735AA Sequence: ELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVSAQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQCKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASSVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGSWNPLLAKCVSRSISGTag info: N-terminal 6xHis-taggedExpression Region: 41-405aaProtein length: PartialMW: 44.5 kDaAlternative Name(s): Complement regulatory protein Crry Protein p65Relevance: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.Reference: "The murine complement receptor gene family: III. The genomic and transcriptional complexity of the Crry and Crry-ps genes." Paul M.S., Aegerter-Shaw M., Cepek K., Miller M.D., Weis J.H. J. Immunol. 144:1988-1996(1990)Purity: Greater than 85% as determined by SDS-PAGE.Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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