>Several Other Sizes Are Also Available. Please Inquire. Default Size: 200ugUpdated Date: Stock Protein updated on 20171018Research areas: Signal Transduction Target / Protein: Calm1Biologically active: Not TestedExpression system: E.coliSpecies of origin: Rattus norvegicus (Rat)Delivery time: 3-7 business daysUniprot ID: P0DP29AA Sequence: ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAKTag info: N-terminal 6xHis-SUMO-tagged and C-terminal Myc-taggedExpression Region: 2-149aaProtein length: Full Length of Mature ProteinMW: 34.2 kDaAlternative Name(s): Calm, Cam, Cam1, CaMIRelevance: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.Reference: "Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association." Edlund M., Blikstad I., Obrink B. J. Biol. Chem. 271:1393-1399(1996)Purity: Greater than 85% as determined by SDS-PAGE.Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
