Controls Estrus for Predictable Mare Breeding Management Product Description Regu-Mate (altrenogest) Oral Solution is a veterinary-prescribed hormonal therapy for mares that suppresses estrus to support controlled breeding schedules and reproductive management. By providing a synthetic progestin effect, it enables a predictable return to heat after withdrawal, helping veterinarians and breeders manage prolonged estrus, transition season irregularities, and planned breeding programs with greater efficiency. Pregnant women or those who suspect pregnancy should avoid handling Regu-Mate (altrenogest) Solution 0.22%. Benefits Estrus Suppression: Effectively suppresses estrus behavior in approximately 95% of mares within three days of administration Predictable Cycling: Supports a predictable return to estrus four to five days after treatment withdrawal in cycling mares. Breeding Management: Facilitates scheduled breeding programs by effectively synchronizing estrus cycles in individual mares or groups. Transition Support: Helps mares achieve regular reproductive cycles during the seasonal transition from winter anestrus to breeding season. Prolonged Estrus Control: Assists in managing mares experiencing prolonged or irregular estrus during transitional reproductive phases. Variants 1000 ml Ingredients Altrenogest 2.2 mg/ml How to Use Recommended-Dosage Chart Approximate Weight (lb) Dose (ml) 770 7 880 8 990 9 1100 10 1210 11 1320 12 Dosage & Administration Instructions Daily Administration: Administer orally at 1 ml per 110 pounds body weight once daily for fifteen consecutive days. Oral Delivery: Administer the solution directly onto the base of the mare’s tongue, or you can mix it in with her regular grain feed. Protective Handling: Make sure to wear protective gloves when drawing and giving the solution to avoid any accidental skin absorption. Proper Dispensing: Attach a luer lock syringe (without a needle) to the dispensing cap, and be careful not to remove it while it’s upside down. Prescription Required: This should only be used under the guidance or supervision of a licensed veterinarian, as federal law limits its administration. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Uterine Conditions: Do not use in mares with current or past uterine inflammation, such as acute or chronic endometritis. Pregnancy Handling: Pregnant women or those who think they might be pregnant should avoid handling this product due to the risk of hormonal absorption effects. Skin Exposure: Avoid direct skin contact since the active ingredient is easily absorbed through healthy human skin. Medical Conditions: People with thromboembolic disorders, liver disease, or hormone-dependent tumors should not handle this product. Possible Side Effects Hormonal Effects: Continuous exposure in humans could result in menstrual disruptions, cramping in the uterus, changes in bleeding patterns, or even longer pregnancies. Headache Risk: Those who accidentally absorb progestin through their skin might find themselves dealing with headaches. Oil Aspiration: If someone accidentally ingests the oil-based product, it could lead to complications that require medical attention. Storage Information Temperature Control: Store at or below 25°C or 77°F to maintain product stability and effectiveness. Child Safety: Keep out of reach of children to prevent accidental exposure or ingestion risks. Secure Container: Replace the dispensing cap cover after each use to prevent leakage or contamination of the solution. Shipping & Return We offer ground, express, priority, and international delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What is Regu-Mate used for in mares? Ans: Regu-Mate is prescribed to suppress estrus in mares, allowing a predictable return to heat after treatment withdrawal. It helps veterinarians and breeders manage reproductive cycles, schedule breeding, and control prolonged estrus behavior during transitional reproductive periods under veterinary supervision from Merck Animal Health. Q2: How quickly does Regu-Mate suppress estrus in mares? Ans: Research shows that around 95% of mares will have their estrus suppressed within three days of beginning treatment. The timing for when they return to estrus after stopping the therapy varies based on their ovarian activity, but usually, cycling mares will start showing signs of heat again in about four to five days. Q3: How is Regu-Mate administered to horses? Ans: Regu-Mate is given orally once daily at a dose of 1 ml per 110 pounds of body weight for fifteen consecutive days. It can be administered directly onto the base of the tongue or mixed with the mare’s regular grain ration. Q4: Are there safety precautions when handling Regu-Mate? Ans: Yes, protective gloves must be worn because altrenogest is absorbed through human skin. Pregnant women or those who may be pregnant should not handle the product. Accidental exposure may disrupt menstrual cycles or cause other hormonal effects, requiring immediate washing. Q5: Can Regu-Mate be used in all mares? Ans: Regu-Mate should not be used in mares with current or past uterine inflammation, such as endometritis, as hormonal therapy may worsen infections. It is also restricted to veterinary prescription use and should only be administered under professional guidance.
