Di-Indolyl-Methane (DIM) is a brassica vegetable metabolite sometimes used by healthcare practitioners to promote favourable hormone metabolism and balance. DIM is a metabolite derived from the Brassica family of vegetables. A portion of ingested Indole-3-carbionol (I3C) from Brassica vegetables can be converted and absorbed in the small intestine as the dimer, DIM, an acid catalysed stable compound. The amount of DIM that can be formed from I3C is variable, and is dependant on numerous gastrointestinal and physiological conditions. Furthermore IC3 can also convert to alternate and less desirable metabolites other than DIM. DIM has been shown to selectively bind to oestrogen receptors, yet may act as an oestrogen antagonist at certain physiological concentrations, potentially providing a regulatory role. DIM promotes oestrogen metabolism down the more ‘protective’ 2-OH phase 1 pathway, reducing the amount of oestrogen metabolised into the more proliferative or DNA destabilising 4-OH and 16-OH pathways, in those with high levels of these metabolites. This more favourable regulation and metabolism of oestrogens may confer both short and long term benefits in numerous hormone influenced conditions, risks and disease states. Dose: As prescribed by your healthcare professional. Amount per Scoop: 75mg Ingredients: Diindolylmethane (DIM) Warnings: Doses over 300mg may be associated with headaches and gastrointestinal complaints. DIM has not been extensively tested for its effects during pregnancy. Because of its potential effect on hormones, health practitioners may prefer to avoid its use during pregnancy or lactation, unless confident that its impact can be reasonably deemed to be safe and beneficial. Prescription only. Only to be used under the supervision of your healthcare professional.
