RN Labs Methyl Fortify contains a balanced and synergistic blend of methylfolate (L-5MTHF), methyl-B12, and choline, each serving as an external source of methyl (CH3) groups to the body. RN Labs Methyl Fortify is invaluable invaluable for delivering highly focused clinical methylation support, and the optimisation of cardiovascular, neurological and detoxification function. Activated vitamin B2 and B6 provide additional cofactor support for optimum metabolism. A balanced and synergistic blend of methylation-supportive B vitamins Provides the externally methylated forms of folate and vitamin B12 Activated forms of vitamin B2 and B6 provide crucial co-factor support for the proper metabolism of folate, B12 and methylation Provides a therapeutic dose of choline for support of the alternate Betaine-homocysteine S methyltransferase (BHMT) homocysteine methylation pathway May help to support the maintenance of normal, healthy homocysteine levels via remethylation back to methionine Provides vitamin B6 for conversion of homocysteine to cysteine via the transulfation pathway Supports the synthesis of glutathione Vitamin B2 is a component of glutathione reductase and a crucial cofactor in the activity of MTHFR Choline may support normal lipid metabolism Choline assists in the synthesis of SAMe Directions: Adults take 1 capsule daily or as prescribed by your healthcare practitioner. Ingredients: Each Vegetarian Capsule Contains: Riboflavin-5-Phosphate sodium 31.7 mg Equiv to Riboflavin 25 mg Pyridoxal-5-Phosphate (P5P) 29.2mg Equiv. to Pyridoxine 20 mg Calcium L-5-methyltetrahydrofolate 550 micrograms Equiv. Levomefolate Calcium 500 micrograms Mecobalamin (co-methylcobalamin) 1000 micrograms Choline Dihydrogen Citrate 300 micrograms Warnings: FOR PRACTITIONER DISPENSING ONLY. This product contains Pyridoxal-5-Phosphate which may be dangerous when used in large amounts or for a long time. If symptoms persist consult your healthcare practitioner. Vitamin supplements should not replace a balanced diet. Known Side Effects: In doses typically administered for therapeutic purposes, 5-MTHF is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported. Whilst some concern exists that supplementation with high doses of folic acid could mask a vitamin B12 deficiency, supplementation with 5-MTHF appears to sidestep this potential problem. Since 5-MTHF can only be converted to 5,10-methylenetetrahydrofolate (involved in DNA synthesis) after participating in homocysteine recycling with vitamin B12, 5-MTHF will not mask a B12 deficiency.