Rx Comfortis® (spinosad) for Dogs and Cats, Kills fleas and prevents infestations Comfortis is a new and unique way to defend your cat or dog against fleas. Protection comes in the form of an easy-to-give, beef-flavored tablet that starts killing fleas within 30 minutes and keeps them from laying eggs. Your pet is safeguarded for a full 30 days. Unlike topical flea treatments, Comfortis isn't messy. It won't leave a staining residue on your pet's fur, and there's no isolation period for your pet while the spot-on fluid dries, so you can play with your pet immediately after administration. How it works:Spinosad kills fleas by causing excitation of the insect's nervous system, leading to paralysis and rapid death. Comfortis is safe for dogs 3.3 pounds or more; cats 2 pounds or more; and puppies and kittens 14 weeks or older. This product requires a Valid prescription. All prescription items are Non-Refundable and Non-Returnable.