SAMe Liquid gives you S-adenosyl-L-methionine in purified water, the form that keeps its potency. Each 5ml spoonful provides 50mg of SAMe and you take one spoonful a day in water, with food. One 100ml bottle holds 20 servings. Benefits of taking SAMe SAMe is a compound the body makes from methionine and ATP and uses as its main methyl donor, handing a methyl group to more than a hundred reactions, including the pathway that processes homocysteine and the ones that make neurotransmitters. It is unstable as a powder, which is why most products are coated tablets. A water based liquid keeps its potency in the fridge and lets the amount start low. Each spoonful gives a fixed 50mg, a low starting amount that a practitioner can build on. Nothing else is in the bottle apart from purified water. Potency holds in the fridge, where a powder would break down. Swallowing is easy, because it is a liquid rather than a coated tablet. Who benefits SAMe Liquid is most useful for: People whose practitioner has suggested SAMe within a methylation routine alongside B12, folate and B6. Anyone who wants a low starting amount they can adjust by the spoonful. Those who prefer a liquid to a coated tablet. If you are building a methylation routine, Vitamin B12 Methylcobalamin Drops and L-Methylfolate 5-MTHF Capsules are the two it is most often taken with. What is in it Each 5ml spoonful provides 50mg of S-adenosyl-L-methionine. The only other ingredient is purified water. There is no authorised health claim for SAMe, so Nutri Tailor describes it by what it contains. How to take it Take one 5ml spoonful a day mixed into water, with food. Keep the bottle in the fridge once it is open. Diet and allergens The liquid is suitable for vegans and vegetarians. It is free from gluten, dairy and nuts. Quality The liquid is made in the UK in a GMP certified cleanroom facility accredited to ISO 9001 and ISO 14001. Every batch is traceable from raw material to finished product. Like every supplement Nutri Tailor stocks, it is practitioner grade and guaranteed additive free. Common questions What does SAMe do in the body? It is the body's main methyl donor, handing a methyl group to more than a hundred reactions, including the step that processes homocysteine and the ones that make neurotransmitters. How much SAMe should I take a day? One 5ml spoonful, which gives you 50mg. A 100ml bottle lasts 20 days at that amount. If a practitioner has advised more, follow their advice. When is the best time to take it? With food, at any time of day. Mix the spoonful into water and keep the bottle refrigerated once opened. Why is SAMe sold as a liquid? SAMe is unstable as a powder, which is why most products are coated tablets. A water based liquid keeps its potency when refrigerated and lets the amount start low. Can I take it with other supplements? Yes. It is usually taken within a methylation routine alongside Vitamin B12 Methylcobalamin Drops, L-Methylfolate 5-MTHF Capsules and vitamin B6. Does SAMe have side effects? It is well tolerated at one spoonful a day with food. If you take prescribed tablets, are pregnant or breastfeeding, speak to your GP or pharmacist first. Delivery and returns Order before 2pm Monday to Friday and your bottle is dispatched the same day from the UK. Standard UK delivery by Royal Mail Tracked 48 takes 2 to 4 working days and costs £3.35, or it is free when you spend £35 or more. Faster delivery is available at checkout. Nutri Tailor also ships worldwide, with duties and taxes shown before you pay. You can return unopened items within 30 days of delivery. New customers get 10% off their first order. Why Nutri Tailor Nutri Tailor is rated 4.6 out of 5, "Excellent", on Trustpilot. Every supplement is chosen by experienced nutritional therapists. Kasia Key, Registered Associate Nutritionist, says: "I use Nutri Tailor for myself and my clients because you can be certain that their supplements are industry leading quality." Sources The information on this page comes from the product label.