Support mood, joint comfort and liver function with S adenosylmethionine S Adenosyl L Methionine (SAMe) is a naturally occurring molecule found in every cell that serves as the body's primary methyl donor, participating in over 100 methylation reactions. Each 5ml spoonful provides 50mg of SAMe in a liquid format (purified water base). SAMe is involved in three critical metabolic pathways: methylation (gene expression, neurotransmitter metabolism, detoxification), transsulfuration (glutathione production) and aminopropylation (polyamine synthesis for cell growth).SAMe has been extensively studied for mood support, joint comfort and liver health. In the methylation cycle, SAMe donates its methyl group to produce neurotransmitters including serotonin, dopamine and noradrenaline. SAMe is involved in methylation and has been studied for its role in supporting a balanced mood. For joints, SAMe supports cartilage proteoglycan production. For the liver, it supports glutathione synthesis and phospholipid methylation essential for bile flow and hepatocyte membrane integrity. The liquid format provides better stability than many tablet forms, as SAMe is inherently unstable and degrades quickly when exposed to moisture. Key benefits: Better mood and emotional balance Joint comfort and cartilage support Liver methylation and detox 5ml spoonful contains: Amount %NRV* S-Adenosyl-L-Methionine 50 mg † † Nutrient Reference Value (NRV*) not established Purified Water, S- Adenosyl-L-Methionine. Directions for use:Take 1 x 5ml spoonful per day mixed into water, with food.SAMe is best taken in the morning, as its effects on neurotransmitter production can be mildly stimulating. Mixing into a small glass of water ensures even distribution. Taking with food improves tolerability.For mood support, allow 2 to 4 weeks to assess the effect. SAMe works within the methylation cycle and benefits from adequate B12, folate and B6 status. If using SAMe for mood, ensure these B vitamins are also being supplemented, as they are cofactors in the same pathway. Store refrigerated after opening to preserve stability.