Methyl Donor for Mood, Joints & Methylation SAMe (S-adenosyl-L-methionine) is one of the body's most important methyl donors, participating in dozens of biochemical reactions. This 400 mg formula supports glutathione production, healthy liver function, musculoskeletal and joint comfort, and a positive, balanced mood. Why You'll Love It Positive mood — supports a healthy, balanced mood Joint comfort — supports musculoskeletal and joint comfort Methylation & glutathione — donates methyl groups and supports glutathione production Liver support — supports healthy liver function How to Use Take as directed on the product label, or as recommended by your healthcare practitioner. Important: because SAMe affects mood-related neurotransmitters, do not combine it with antidepressants or other serotonergic medications (such as SSRIs, SNRIs, or MAOIs) without practitioner guidance, as this can lead to serotonin syndrome. SAMe is not recommended for people with bipolar disorder, as it may trigger mania. If you are pregnant or nursing, take medications, or have a medical condition, consult your healthcare practitioner before use. Key Ingredients SAMe (S-adenosyl-L-methionine) 400 mg. To support healthy methylation, pair with Methyl B-Complex. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.