Feeling low or stiff? SAMe by Jarrow Formulas is a multi-benefit supplement that supports mood balance, joint comfort and liver detox. It works by promoting healthy methylation — a key process for brain chemicals and inflammation regulation. Ideal if you're looking for natural support for mental wellbeing and mobility in one. Contains More of the Active S,S Form than R,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available. SAMe increases a chemical in the brain called serotonin. Some medications used for depression also increase serotonin. Please note taking SAMe along with these medications used for depression might cause too much serotonin in the body. (new package design)