Precise, buffered copper that's safer on your fish.Ich and velvet can wipe out a tank fast — but old copper sulfate and citrate treatments are harsh, unstable, and easy to overdose.Seachem Cupramine is a buffered, amine-complexed copper that's active at low concentrations, non-acidic, and far less toxic to fish than copper sulfate, chloride, or citrate. It stays in solution, won't contaminate the filter bed, and is 100% removable with carbon or CupriSorb. There's a wide safety gap between the therapeutic dose (0.2 mg/L) and the toxic dose (0.8 mg/L).Cupramine reflects the science-driven chemistry Seachem has practiced since it was founded in 1979 in Madison, Georgia. As a company whose products are developed and manufactured in-house by chemists and backed by research, Seachem engineered Cupramine as a buffered amine copper that stays in solution and won't contaminate the filter bed — and it's 100% removable with activated carbon or CupriSorb once treatment is complete. Remove all invertebrates and chemical filtration; do not combine with other medications or reducing agents (conditioners, ammonia binders). Dose 1 mL (20 drops) per 40 L (10.5 US gallons); wait 48 hours, then repeat. Hold 0.5 mg/L (0.25 mg/L in freshwater) for 14 days, testing with MultiTest Copper. Beat parasites without poisoning your fish. Add to cart.Why Seachem Cupramine Buffered amine copper, safer than copper sulfate: active at low concentrations, non-acidic, and far less toxic to fish than copper sulfate, chloride, or citrate, with a wide safety gap between the therapeutic dose (0.2 mg/L) and the toxic dose (0.8 mg/L). Stays in solution and won't contaminate the filter bed: it holds a stable therapeutic level rather than crashing out like older coppers. 100% removable with carbon or CupriSorb: pull copper back out completely when treatment is done. Precise Seachem chemistry: a research-backed formula meant to be dosed and held to an exact level, verified with MultiTest Copper. Best ForUse Cupramine in freshwater and marine fish-only or quarantine tanks to treat external parasites — ich/white spot (Ichthyophthirius, Cryptocaryon), velvet (Piscinoodinium, Amyloodinium), Oodinium, and other ectoparasites. It is ideal for a dedicated quarantine or treatment tank where copper can be held at a precise level. It is NOT safe for reef tanks or invertebrates — invertebrates are extremely copper-sensitive, so remove all invertebrates before use and never dose a reef or invertebrate system.What It TreatsExternal parasites of freshwater and marine fish — ich/white spot (Ichthyophthirius, Cryptocaryon), velvet (Piscinoodinium, Amyloodinium), Oodinium, and other ectoparasites. Not safe for reef tanks or invertebrates.DirectionsBefore treating: Remove all invertebrates (extremely copper-sensitive). Turn off UV and ozone filters and remove chemical filtration (MatrixCarbon, Purigen). Do not use with any other medication or with reducing agents (conditioners, ammonia binders).Treatment: Use 1 mL (20 drops) per 40 L (10.5 US gallons) the first day; wait 48 hours, then repeat. In freshwater, use half dose. Final copper concentration is 0.5 mg/L (0.25 mg/L in freshwater). Hold for 14 days. Do not redose without testing (MultiTest Copper). Although most fish tolerate up to 0.8 mg/L, do not exceed 0.6 mg/L.After treating: Remove with carbon or CupriSorb; leave copper-absorbing media in for at least a week after copper reaches 0.Available Sizes50 mL, 100 mL, 250 mL, 500 mL, 2 L, 4 LWarningFor ornamental fish only. Keep away from children. In case of eye exposure, wash thoroughly with water and seek medical attention.FAQIs Cupramine safe for reef tanks or invertebrates? No. Invertebrates are extremely copper-sensitive, so Cupramine must never be used in a reef or invertebrate tank. Remove all invertebrates before treating, and dose only in a fish-only or quarantine tank.How do I remove Cupramine after treatment? Cupramine is 100% removable with activated carbon or CupriSorb. Leave copper-absorbing media in for at least a week after copper tests at 0.Will Cupramine affect my ammonia test or should I use conditioners with it? Do not combine Cupramine with reducing agents such as water conditioners or ammonia binders, as they can interfere with the treatment — and always verify the copper level with MultiTest Copper before redosing rather than dosing blind.
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