Seachem Safe Safe is the complete and super-concentrated dry conditioner for both fresh and salt water. Safe removes chlorine, chloramine and detoxifies ammonia, nitrite, and nitrate. It is non-acidic and will not impact pH. Safe may be used during tank cycling to alleviate ammonia/nitrite toxicity. It contains a binder which renders ammonia, nitrite, and nitrate non-toxic, allowing the biofilter to more efficiently remove them. Use at start-up and whenever adding or replacing water. Directions: 50 gram: Use 200 mg of Safe™ (included scoop) per each 200 L (50 US gallons) as needed to reduce chlorine and chloramine or per 50 L (13 US gallons) for ammonia. All other sizes: Use 1.25 g (1/4 tsp.) for every 1,250 L (300 US gallons) as needed to reduce chlorine and chloramine or use 1.25 g (1/4 tsp.) for every 300 L (75 US gallons) for ammonia. For precise dosing, use the Seachem Digital Spoon Scale.