Seachem StressGuard is a premium slime-coat protectant and stress reducer for freshwater and saltwater aquariums. It calms fish and lowers ammonia toxicity during handling, transport, and acclimation, and it binds to exposed protein in wounds to support healing and reduce the risk of infection. Browse more Seachem water care in our maintenance and water care section. Why StressGuard Protects the slime coat: reinforces the fish's natural barrier against stress and disease. Reduces stress and ammonia toxicity: ideal when moving, bagging, or introducing new fish. Supports wound healing: binds to exposed protein in damaged tissue to discourage primary and secondary infection. Filter and media friendly: not amine based, so it will not interfere with Purigen or HyperSorb, and it will not coat resins or clog filtration the way some slime-coat products do. Medication compatible: safe to use alongside all medications except copper-based treatments. Fresh or salt: works in both freshwater and marine systems. Choose Your Size Size Approx. doses* Best for 50 mL ~10 capfuls Nano tanks and occasional use 100 mL ~20 capfuls Small to medium tanks 250 mL ~50 capfuls Busy tanks and frequent handling 500 mL ~100 capfuls Large systems, breeders, and shops *One 5 mL capful treats about 10 US gallons (40 L). How to Use Shake well before use. Add 5 mL (one capful) for every 40 L, about 10 US gallons. For new arrivals, handling, or transport, dose at the time of the event. For injured fish, you can dose daily until healed. Safe to use with all medications except those that are copper based. Specifications Product Slime-coat protectant and stress reducer Use Freshwater and saltwater aquariums Dose 5 mL per 40 L (about 10 US gallons) Compatibility All medications except copper based; filter and resin safe Sizes 50 mL, 100 mL, 250 mL, 500 mL Brand Seachem, made in the USA Good to Pair With A quality water conditioner whenever you add new water (browse maintenance and water care). More additives and supplements from Seachem. FAQ When should I use StressGuard? Any time fish are stressed: during transport, netting, acclimating new fish, or after an injury. Is it safe with my filter media? Yes. It is not amine based, so it will not interfere with Purigen or HyperSorb, and it will not clog filtration. Can I use it with medications? Yes, with all medications except copper-based treatments. Fresh or salt water? Both. StressGuard works in freshwater and marine aquariums.
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