Semaglutide

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Semaglutide is a long-acting GLP-1 (glucagon-like peptide-1) receptor agonist with 94% sequence homology to native human GLP-1. It features a C18 fatty diacid chain attached via a linker to lysine at position 26, enabling albumin binding and extended half-life of approximately 7 days in research models. Originally developed as an analog of GLP-1(7-37), Semaglutide has been extensively studied for its role in glucose-dependent insulin secretion support, glucagon suppression, gastric emptying regulation, and hypothalamic appetite signaling in metabolic and neuroendocrine research models. Show more