Klaire Labs SeraBella™ Plus (Phosphatidyl Serine) Supports Brain and Nerve Function Phosphatidylserine is the most abundant phospholipid in your brain. It is an essential part of healthy neuron membranes and vital for proper cell function, including carrying signals throughout your brain, promoting cognitive function, emotional well-being, and behavioral performance. It has also been shown to support effective memory. In a six-month double-blind, placebo-controlled multi-center study of 425 people, daily phosphatidylserine supplementation resulted in statistically significant support of behavioral and cognitive parameters. In a placebo-controlled study of 149 subjects, the group receiving phosphatidylserine outperformed the placebo group in performance tests related to daily memory tasks. Phosphatidylcholine is a naturally occurring, integral component of the cellular membrane that adds fluidity and strength to cells. It contains choline, which is necessary for methylation, cell-to-cell communication, cognition, and liver function. Choline and its metabolites are the primary dietary sources of methyl groups. Methylation is involved in many processes, including neurotransmission, vitamin absorption, DNA synthesis, and gene regulation. Choline is required for the synthesis of phospholipids as well as the synthesis of acetylcholine, a neurotransmitter involved in attention, learning, and memory. Certain genetic variations in MTHFR and PEMT, enzymes involved in methylation and choline synthesis, respectively, have been linked to increased dietary choline requirements. According to research, pregnant women with PEMT and MTHFR genetic variations should consume more choline. Another clinical trial discovered that pregnant women with PEMT and MTHFR genetic variations who consumed 480 mg of choline daily had offspring with faster processing speed than those who did not. PC is also important in the proper transport and metabolism of lipids. According to a randomized, double-blind, placebo-controlled trial, choline-containing lecithin may help support healthy hepatic fat metabolism. According to animal studies, PC promotes healthy liver and pancreatic antioxidant activity. Promotes healthy brain cell structure and function to support memory, learning, cognitive function, and mood. SeraBella™ Plus promotes healthy brain cell structure and function to support memory, learning, cognitive function, and mood. Key Benefits and Features: Supports cognitive function and emotional well-being Supports working memory Promotes healthy aging and behavioral performance, including tasks of daily life Supports healthy phospholipid balance in cell membranes Ingredients Serving Size: 1 Softgel Amount/Serving Phospholipid Complex (from soy lecithin) 500 mg Phosphatidylserine 100 mg Phosphatidylcholine 25 mg Phosphatidylethanolamine 2.5 mg Other Ingredients: Gelatin, glycerin, polyglycitol syrup, and water. Contains: Soy. Does Not Contain: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat/gluten, sesame, synthetic colors, or flavors. Suggested Use Adults: 1 softgel, 1 to 2 times daily, with food, or as directed by a healthcare professional. Children: As directed by a healthcare professional. Warning: Consult with your physician if you are pregnant or lactating, have a medical condition, are taking prescription drugs, or are under the age of 18 years. KEEP OUT OF REACH OF CHILDREN. Storage: Store at room temperature (59°F-85°F). More Info Phosphatidylserine (PS) is an endogenous phospholipid. Although it is less abundant in the body than other phospholipids (i.e., phosphatidylcholine and phosphatidylethanolamine), it still comprises 2–10% of the body’s total phospholipids, with critical functions in several biological areas, such as apoptosis (programmed cell death), blood clotting, and cell-to-cell communication. The PS molecule consists of a glycerol-phosphate backbone, the alpha-amino acid serine, and two fatty acids. As with other phospholipids, PS is a critical component in the structure of membranes, particularly neurons. In the body, phospholipids form a variety of structures owing to their amphipathic nature, i.e., having both a hydrophobic (“water-fearing”) non-polar tail and hydrophilic (“water-loving’) polar head. They can move within the fluid mosaic of cell membranes, which supports cellular communication, selective passage of macromolecules, and other important cellular functions. Phosphatidylserine is the most abundant negatively charged phospholipid in eukaryotic cell membranes. As the major acidic phospholipid in the brain, PS can traverse the blood-brain barrier after oral administration. In animal studies, it has been shown to influence several neurochemical systems, neuronal membranes, cell metabolism, and several neurotransmitters, including serotonin and dopamine. Several clinical trials have shown that PS supplementation supports cognitive function. In one randomized, controlled clinical trial, 36 children, aged 4 to 14 years, who were experiencing attention-related issues were given 200 mg/d of PS or placebo for two months. PS supplementation resulted in significant improvements in attention, impulsive movement, and short-term auditory memory as compared with placebo. PS was well-tolerated and showed no adverse effects. Phosphatidylserine has further been shown to support healthy endocrine and adrenal responses to mental stress. In a double-blind study, PS (400 mg, 600 mg, or 800 mg/d) was administered to healthy women and men 20 to 45 years old. In the groups receiving 400 mg/d of PS only, researchers observed a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the Trier Social Stress Test (TSST). There was also a positive effect on emotional responses to the TSST at 400 mg/d. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PS showed a decrease. The effect was not seen with larger doses. These results suggest that PS may dampen hypothalamic-pituitary-adrenal (HPA) axis stress responses. Phosphatidylserine also supports cognitive function in aging individuals. In a clinical trial, 70 elderly subjects with cognition complaints were randomly allocated to four groups: 17 patients received only social support, 18 patients received cognitive training twice a week, 17 patients received cognitive training combined with pyritinol 2 x 600 mg/d, and 18 patients received cognitive training combined with phosphatidylserine (200 mg BID). Researchers concluded that PS supplementation combined with cognitive training led to transient improvement of cognitive and memory function, as well as improved electrophysiological brain function.
