Skeletal Function and Form: Mechanobiology of Skeletal Development, Aging, and Regeneration

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Dennis R. Carter, Gary S. BeaupréCambridge University Press, 1/25/2001EAN 9780521790000, ISBN10: 052179000XHardcover, 332 pages, 25.3 x 17.7 x 1.9 cmLanguage: EnglishThe intimate r elationship between form and function inherent in the design of animals is perhaps nowhere more evident than in the musculoskeletal system. In the bones, cartilage, tendons, ligaments, and muscles of all vertebrates there is a graceful and efficient physical order. This book is about how function determines form. It addresses the role of mechanical factors in the development, adaptation, maintenance, ageing and repair of skeletal tissues. The authors refer to this process as mechanobiology and develop their theme within an evolutionary framework. They show how the normal development of skeletal tissues is influenced by mechanical stimulation beginning in the embryo and continuing throughout life into old age. They also show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence development and growth. Skeletal Function and Form bridges important gaps among disciplines, providing a common ground for understanding, and will appeal to a wide audience of bioengineers, zoologists, anthropologists, palaeontologists and orthopaedists.Preface1. Form and function2. Skeletal tissue histomorphology and mechanics3. Cartilage differentiation and growth4. Perichondral and periosteal ossification5. Endochondral growth and ossification6. Cancellous bone7. Skeletal tissue regeneration8. Articular cartilage development and destruction9. Mechanobiology in skeletal evolution10. The physical nature of living thingsAppendix A. Material characteristicsAppendix B. Structural characteristicsAppendix C. Failure characteristicsIndex.'... readers with an interest in skeletal form and function will gain new understanding of the possible roles of physical forces in skeletal tissue processes ... and will be drawn to wonder about the physical, biological, and evolutionary mechanisms responsive for skeletal tissue function and form.' Richard T. Hart, Journal of Biomechanics Show more