skinbetter science AlphaRet Overnight Cream is the breakthrough physician-developed overnight treatment that proved retinoid skincare doesn't have to come at the cost of tolerability. In a 12-week clinical study comparing AlphaRet to 1.0% retinol and 0.025% tretinoin, AlphaRet was the only product to achieve statistically significant improvements in wrinkle reduction while simultaneously outperforming retinol on redness reduction and pore appearance — all with a significantly higher patient tolerability rating than both comparators.The secret is AlphaRet Technology — a patented, double-conjugated molecule (Ethyl Lactyl Retinoate) that chemically bonds a retinoid with lactic acid into a single compound. This conjugation allows the retinoid to work at a clinically effective level while the lactic acid component neutralizes much of the surface irritation, delivering visible skin rejuvenation with little-to-no irritation even for patients with reactive or rosacea-prone skin. Glycolic Acid enhances AlphaRet's performance and retexturizes the skin's surface. Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 (Matrixyl 3000) smooth wrinkles and improve firmness. Ceramide NP, Squalane, Niacinamide, and Hyaluronic Acid counteract retinoid-induced dryness. Vitamins C and E, CoQ10, and Superoxide Dismutase provide comprehensive antioxidant protection.Apply a thin layer to the face in the evening. Begin 2–3 times weekly, increase to nightly as tolerated. Not for use during pregnancy. Use daily SPF 30+. Available at Beauty Riche — authorized skinbetter science retailer with same-day shipping.