Patient Type: Muscle aches and spasms Athletic recovery Sleep How to Dose: 1-2 capsules three times per day How Does Sleep Support Work: Both GABA and glycine act as calmatives for nerve impulses, controlling muscle contractions. Dong quai root extract has been used for centuries in Chinese traditional medicine to increase relaxation of the smooth muscles. GABA itself is the primary inhibitory neurotransmitter in the brain and regulates other neurotransmissions to prevent overstimulation. o One study found that after only 60 minutes of administration, GABA significantly increased alpha brain waves and decreased beta waves compared to water or L-theanine, indicating a significant calming effect on the nervous system. Glycine is one of three amino acids needed for the synthesis of creatine, which supplies energy to nerve and muscle cells. o Glycine is the primary amino acid that regulates neurotransmission in the brain stem and spinal cord and is a necessary co-factor in the activation of glutamate receptor. This action makes glycine a key component of maintaining nervous system balance and maintaining calm, relaxed muscles. Dong quai contains active ingredients called coumarins, which dilate blood vessels, balance the central nervous system and increase blood flow. Vitamin B6 is required to convert glutamic acid to GABA in the body. It is also a cofactor in many cellular biochemical reactions, including the release of glucose from glycogen and amino acid metabolism, including transamination, deamination and decarboxylation. Magnesium plays a significant role in regulating the influx of calcium into muscle cells. Therefore, calcium can remain in the muscle cell for a longer period when magnesium is depleted, leading to cramping or muscle spasms.
