A standardized botanical formulation designed to support vasomotor stability and hormonal balance during menopause. Each serving provides 30 mg of Soy Isoflavones, independently verified at 132% potency (≈ 19–20 mg Genistein). All batch testing and Certificates of Analysis are available in the Menopause Science Trust Center. Our Hot Flash & Hormone formulation targets: Hot flash frequency and severity Mood variability Night sweats Sleep quality Hormonal equilibrium Primary Active Ingredient Genistein (from Soy Isoflavones): ~19–20 mg per serving This formulation combines Genistein-rich Soy Isoflavones with a complementary botanical matrix: Black Cohosh Root Extract Dong Quai Root Extract Red Clover Chasteberry Extract Secondary actives include Sage, Licorice, Wild Yam, Red Raspberry, and Resveratrol to provide phytoestrogenic and adaptogenic support for energy, stress resilience, and endocrine balance. Designed to act across multiple physiological pathways associated with menopausal symptoms. Key Characteristics Clinically relevant Genistein dosage (~19–20 mg per serving) Multi-pathway support for vasomotor and hormonal symptoms Independently verified potency Free from hormones, parabens, and synthetic fillers Manufactured in a GMP- and FDA-registered facility Full Ingredient List Soy Isoflavones Black Cohosh Root Extract Dong Quai Root Extract Licorice Root Extract Chasteberry Extract Red Clover Sage Wild Yam Red Raspberry Resveratrol Vegetable Capsule Rice FlourMagnesium Stearate *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Trust Center Verified Comprehensive analysis of clinical research and evidence* Hot Flash & Hormone Support By Menopause Science Hot Flash + Hormone Support is a targeted formula designed to support hormonal regulation and mitigate symptoms associated with estrogen fluctuations.* View Product Research Summary Across these botanicals, menopause-specific trials support reductions in vasomotor symptoms for soy isoflavones, red clover (mixed evidence), and sage; licorice shows a signal for hot flashes in small RCTs; black cohosh evidence is mixed across RCTs and reviews. Dong quai and wild yam have undergone menopause-specific trials, showing no meaningful effect compared to a placebo. For others (e.g., chasteberry), evidence exists in menopausal women, but outcomes can be broader than hot flashes. Where menopause-specific trials don’t exist, we used women-only or mixed-sex human evidence (noted).* Research at a Glance Ingredient Population Studied Studied Benefit(s) Research Link Soy Isoflavones Peri-/postmenopausal women Reduced hot flash frequency and severity vs placebo (meta-analysis of RCTs) View Study Black Cohosh Postmenopausal women Mixed evidence for vasomotor relief; some RCTs show no benefit View Study Dong Quai Women with primary dysmenorrhea (non-menopausal) Reduced menstrual pain severity vs placebo View Study Licorice Root Postmenopausal women Reduced hot flash severity vs placebo in 8-week RCT View Study Red Clover Peri-/postmenopausal women Modest improvement in hot flushes in some trials; overall evidence mixed View Study Sage Leaf Menopausal women with hot flushes Reduced hot flush frequency and severity; improved symptom scores (open-label study) View Study Chasteberry (Vitex agnus-castus) Peri-/postmenopausal women Reduced menopausal symptom scores vs placebo over 8 weeks View Study Blessed Thistle Healthy adults (mixed-sex) Increased gastric acid secretion; used traditionally as a digestive bitter (review) View Study Red Raspberry (Rubus idaeus) Adults at risk of metabolic syndrome (67% women) Improved immune and metabolic biomarkers after 8-week supplementation with red raspberry powder View Study Wild Yam Healthy postmenopausal women No significant hormonal changes; traditionally used for menstrual symptoms View Study trans-Resveratrol Postmenopausal women Improved menopause-related quality of life and reduced pain; not vasomotor-specific View Study Plain Language Summary The ingredients in Hot Flash Support have been studied for their effects on women’s health, particularly in reducing hot flashes and supporting overall comfort during menopause. Research in menopausal women shows that soy isoflavones, black cohosh, licorice root, red clover, sage leaf, chasteberry, and trans-resveratrol can reduce hot flash frequency or severity, improve symptom scores, or enhance quality of life. Some ingredients, such as dong quai and red raspberry, have been studied in women or mixed-sex groups for other health benefits. Dong quai, when used as part of a multi-herb formula, has been shown to reduce menstrual pain in women. Red raspberry powder has been shown to improve insulin function, reduce liver insulin resistance, and lower LDL cholesterol in adults at risk for metabolic syndrome. Other botanicals, like wild yam and blessed thistle, remain included for their traditional use in women’s health, although human trials have not shown proven benefits for menopause or related symptoms. Key Citations Taku K, et al. Meta-analysis of the effects of soy isoflavones on hot flashes in peri- and postmenopausal women. J Nutr. 2012;142(2):356–364. PMID 22433977 Beer AM, et al. Black cohosh in menopausal symptoms – systematic review. Planta Med. 2023;89(9):704–717. PMID 37192826 Chen H, et al. Efficacy of Danggui Shaoyao San for primary dysmenorrhea: systematic review and meta-analysis. J Altern Complement Med. 2016;22(7):541–550. PMID 26857875 Nahidi F, et al. Licorice root extract in postmenopausal hot flashes: randomized double-blind controlled trial. Iran J Pharm Res. 2013;12(1):217–224. PMID 24250477 Baber RJ, et al. Red clover isoflavones for menopausal symptoms. Maturitas. 2021;147:42–50. PMID 33920485 Bommer S, et al. Sage in menopausal hot flushes: open-label trial. Adv Ther. 2011;28(6):490–500. PMID 21630133 Nazari S, et al. Vitex agnus-castus in menopausal symptom management. J Educ Health Promot. 2019;8:97. PMID 31067851 Drugs and Lactation Database (LactMed). Blessed Thistle. 2021. NIH Link Shaughnessy KA, et al. Red raspberry effects on insulin resistance and lipids in adults at risk for metabolic syndrome. J Nutr. 2022;152(6):1438–1449. PMID 35421233 Evans HM, et al. Resveratrol in postmenopausal women: randomized trial. Menopause. 2020;27(8):889–898. PMID 32881835 Tired of Feeling Like a Rotisserie Chicken? Backed by research on key plant-based compounds. Try Hot Flash & Hormone Support by Menopause Science. Shop Now Important Disclaimer FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. FTC Disclaimer: Individual results may vary. The research cited represents studies conducted on individual ingredients and may not reflect the specific formulation of this product.
