Recombinant protein of the receptor binding domain (RBD, short version) of SARS-CoV-2 (COVID-19) Spike S1 from Wuhan pneumonia virus with C-terminal His-Tag. Overview Product Name: SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, short version), His-Tag Catalog No.: P2020-026 RefSeq Links: NC_045512.2; MN908947.3; YP_009724390.1; QHD43416.1; GeneID: 43740568; UniProt: P0DTC2 Synonyms: SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein; 2019-nCoV; COVID-2019; COVID-19 Sequence Information Species: SARS-CoV-2; Wuhan seafood market pneumonia virus Tags: His-Tag, C-terminal Sequence without tags (AA 330-532):MPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTN Product Information Expression Host: human, HEK293 Formulation: PBS, pH 7,4 Format: Liquid, stored and shipped at -80°C Purity: > 90% as determined by SDS-PAGE Background Information The spike (S) glycoprotein of coronaviruses is essential for binding of the virus to the host cell at the beginning of the infection process. The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein is responsible for membrane fusion and is therefore required for virus entry and cell fusion. The target protein is also a major immunogen and a possible target for entry inhibitors.The SARS-CoV-2 spike (S) protein is a large type I transmembrane protein composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) responsible for binding to the host cell receptor angiotensin-converting enzyme 2 (ACE2). The S2 subunit mediates fusion between the viral and host cell membranes. The S1 RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SDS-PAGE/Coll. Coomassie Histogram of marked lane in gel picture Activity of SARS-CoV-2 S1 (RBD, short) Activity of different SARS-CoV-2 S1 (RBD) variants in comparison: Cat. No. P2020-001 (Spike S1 (RBD) and Cat. No. P2020-026 (Spike S1 (RBD, short). Sandwich-ELISA with antibodies from Sino Biological Europe GmbH (coat: #40150-D003 and detection: #40150-D001-H). Download Download Product Information for SARS-CoV-2 Spike S1 Protein (RBD, short)
