Spindle neuron necklace | sterling silver If you can name the two cortical regions where Von Economo neurons concentrate, and tell anyone listening why the elephant and the bottlenose dolphin matter to the comparative-anatomy literature, you already know what the pendant carries. The specialist alternative to the generic neuron pendant. Worn here as a 37 mm sterling silver pendant. The Science Behind the Spindle Neuron Von Economo neurons, also called spindle neurons, were first described by Constantin von Economo and Georg Koskinas in their 1925 cytoarchitectonic atlas of the human cortex, then largely forgotten until Esther Nimchinsky and Patrick Hof revisited the cells in the late 1990s. They are large bipolar projection neurons, three to four times bigger than typical pyramidal cells, concentrated in the anterior cingulate cortex and the frontoinsular cortex. The distribution outside humans is striking: great apes, several cetaceans, elephants, all species with complex social cognition. The cells are implicated in fast salience signalling, self-awareness, and behavioural inhibition. Selective loss of Von Economo neurons in the early stages of behavioural-variant frontotemporal dementia is one of the more reproducible cellular markers in neurodegenerative pathology. Who Tends to Wear This cortical neuroanatomists and comparative neuroscientists frontotemporal dementia clinicians and neuropathologists cognitive neuroscientists working on social cognition or self-awareness graduate students whose thesis touched the Nimchinsky-Hof revival of the 1990s For someone who reaches for spindle neurons when the conversation turns to social cognition or to the neuropathology of behavioural-variant FTD, rather than to the iconic-but-generic neuron of the textbook image. Explore Related Neuroscience Jewelry Neuron necklace | silver Neuron necklace | gold vermeil Neuron earrings | silver Purkinje cell necklace | silver Sagittal brain necklace | gold vermeil FAQ Why pick the spindle neuron over the generic neuron pendant? Because the spindle neuron is a specialist call. The generic neuron is the foundational unit, recognised across all of neuroscience. The spindle neuron is recognised by people whose work specifically engages with anterior cingulate cortex, frontoinsular cortex, social-cognition pathology, or the comparative neuroanatomy of large-brained social mammals. Buying the spindle neuron tells the recipient you know the cell type they care about, not just the cell type that fits on a textbook cover. What makes Von Economo neurons interesting beyond the size? The combination of size, distribution, and clinical signal. They are concentrated in two cortical regions tied to interoception and social processing, they appear preferentially in species with complex social structures, and they are selectively vulnerable in early behavioural-variant FTD. The convergent evolution argument holds that they evolved independently in great apes, cetaceans, and elephants because of shared cognitive demands rather than shared ancestry. The combination of comparative biology and clinical neurology is why the cells caught attention again in the late 1990s and have stayed in the literature since. What size is the pendant and what chain comes with it? 925 sterling silver, 37 mm pendant on a 45 cm sterling silver chain (ø 1.8 mm) with a 5 cm extender. Nickel-free and hypoallergenic. Free worldwide DHL Express in 1-5 business days, with all import duties and taxes covered. 30-day “Love It or Return It” returns. Is there a gold version? Not at present. The spindle neuron is sterling silver only. The generic neuron pendant in 18K gold vermeil exists as a gold counterpart in the same field if a gold neuroscience pendant is the goal.
