Epimune Complex is a vegan immune support supplement designed to help your immune system stand up to challenges. It helps support respiratory health.* Supports specific aspects of immune system activity and contains research-supported ingredients such as EpiCor® and maitake and turkey tail mushrooms* Supports healthy white blood cells* Helps support respiratory health year-round, especially during seasonal challenges* Helps activate and balance a healthy immune system response function* Delivers an excellent source of vitamin C and zinc, both of which provide antioxidant and immune support* Key Ingredients in Epimune Complex Organic Acerola Known as an antioxidant superfruit, Acerola (Malpighia emarginata DC.) is one of the richest plant-based sources of phytonutrients including antioxidant vitamin C1,2 — a key player in a healthy immune system and immune response to seasonal challenges.3,4 Supports mucosa, cell function, skin, blood vessels, and other tissue via its role in collagen synthesis and antioxidant activity Calcium lactate Highly bioavailable calcium that supports numerous actions in the body (involved in cell signaling) Source of dietary calcium: a mineral that supports a healthy immune response including cell signaling in lymphocytes — a type of white blood cell.5,6 Zinc rice chelate Plays a structural role in proteins and helps protect cell membranes while influencing cell communication, hormone release, and cell death Source of dietary zinc: an antioxidant mineral that plays a key role in a healthy immune response4 and cell membrane support.4,7,8 Turkey Tail and Maitake Mushrooms Whole food powders of the mycelium of Grifola frondosa (Maitake) and Coriolus versicolor (Turkey-tail) mushrooms A growing body of research suggests that both Maitake and Turkey Tail mushrooms and extracts provide a variety of health-promoting properties including a healthy immune system support.9-15 Research-supported Ingredients in Epimune Complex EpiCor® EpiCor® is a whole food fermentate comprised of proteins, fibers, polyphenols, vitamins, amino acids and beta glucans that have been clinically shown to provide significant immune health benefits.16-21 MaitakeGold 404® extract MaitakeGold 404® (15%) is a proprietary combination of a certified organic maitake mushroom powder from mycelial biomass (85% by weight) and maitake mushroom fruit body extract (15% by weight) derived under a patented method from the fruit body of Maitake. In an animal study, MaitakeGold 404® has been reported to stimulate phagocytosis (part of the innate immune response) and increase the numbers of some specific immune cells (i.e. phagocytosis monocytes and macrophages).22 In another animal study, short-term oral administration of MaitakeGold 404® strongly stimulated a healthy immune reaction.23 These results indicate a broad-based immune system support that is part of the body’s first line of immune activity.* References: 1. Prakash, A. & Baskaran, R. J Food Sci Technol 55, 3373-3384, doi:10.1007/s13197-018-3309-5 (2018). 2. Cefali, L. C. et al. J AOAC Int 101, 1461-1465, doi:10.5740 jaoacint.18-0008 (2018). 3. Maggini, S., Pierre, A. & Calder, P. C. Nutrients 10, doi:10.3390/nu10101531 (2018). 4. Gombart, A. F., Pierre, A. & Maggini, S. Nutrients 12, doi:10.3390/nu12010236 (2020). 5. Vig, M. & Kinet, J. P. Nat Immunol 10, 21-27, doi:10.1038/ni.f.220 (2009). 6. Feske, S. Nat Rev Immunol 7, 690-702, doi:10.1038/nri2152 (2007). 7. Prasad, A. S. Mol Med 14, 353-357, doi:10.2119/2008-00033.Prasad (2008). 8. Prasad, A. S. Exp Gerontol 43, 370-377, doi:10.1016/j.exger.2007.10.013 (2008). 9. Zhang, Y. et al. Int J Mol Med 40, 1089-1095, doi:10.3892/ijmm.2017.3081 (2017). 10. Chen, P., Liu, H. P., Ji, H. H., Sun, N. X. & Feng, Y. Y. Int J Biol Macromol 125, 1232-1241, doi:10.1016/j.ijbiomac.2018.09.098 (2019). 11. Benson, K. F. et al. BMC Complement Altern Med 19, 342, doi:10.1186/s12906-019-2681-7 (2019). 12. Jeong, S. C. et al. J Med Food 9, 175-181, doi:10.1089/jmf.2006.9.175 (2006). 13. Roca-Lema, D. et al. Int J Med Sci 16, 231-240, doi:10.7150/ijms.28811 (2019). 14. Deng, G. et al. J Cancer Res Clin Oncol 135, 1215-1221, doi:10.1007/s00432-009-0562-z (2009). 15. Leliebre-Lara, V. et al. Molecules 21, doi:10.3390/molecules21081045 (2016)16. Jensen, G. S.; Patterson, K. M.; Barnes, J.; Schauss, A. G.; Beaman, R.; Reeves, S.; Robinson, L. The Open Nutrition Journal 2008, 2, 68-75. 17. Moyad, M. A.; Robinson, L. E.; Zawada, E. T., Jr.; Kittelsrud, J. M.; Chen, D. G.; Reeves, S. G.; Weaver, S. E. Urol Nurs 2008, 28 (1), 50-5. 18. Moyad, M. A.; Robinson, L. E.; Zawada, E. T.; Kittelsrud, J.; Chen, D. G.; Reeves, S. G.; Weaver, S. J Altern Complement Med 2010, 16 (2), 213-8. 19. Moyad, M. A.; Robinson, L. E.; Kittelsrud, J. M.; Reeves, S. G.; Weaver, S. E.; Guzman, A. I.; Bubak, M. E. Adv Ther 2009, 26 (8), 795-804. 20. Jensen, G. S.; Redman, K. A.; Benson, K. F.; Carter, S. G.; Mitzner, M. A.; Reeves, S.; Robinson, L. J Med Food 2011, 14 (9), 1002-10.trial. 21. Jensen, G. S., Carter, S. G., Reeves, S. G., Robinson, L. E., & Benson, K. F. (2015). J Med Food, 18(3), 378–384. 22. Vetvicka, V., et al. JANA 2005, 8(3):33-39. 23. Vetvicka, V. & Vetvickova, J. Ann Transl Med 2, 14, doi:10.3978/j.issn.2305-5839.2014.01.05 (2014). Suggested Use: Two capsules per day, or as directed. Special Information: With MaitakeGold 404® maitake mushroom extract, a registered trademark of the Tradeworks Group, Inc. protected under U.S. Patent 5,854,404. With EpiCor® dried yeast fermentate, a registered trademark of Embria Health Sciences, LLC. Nutrients & Ingredients Each Serving Size (2 Capsules) contains: Total Carbohydrate
