Spanish Black Radish is a detox supplement designed to support liver health with daily use, and support toxin elimination with acute use.* Our research shows that Spanish black radish induces the body's detoxification enzymes in cell and animal models* Supports healthy liver and gallbladder function* Encourages healthy digestion* 3 tablets per day supports the body's normal toxin-elimination function* Contains organically grown Spanish black radish from the Standard Process certified organic farm^ Provides support for the body's organs* ^Ingredients that are not grown on our farm, or if our supply is short, are sourced from certified organic farms. Study Results: Liver Detoxification Standard Process conducted an open-label pilot study to evaluate the efficacy of Spanish black radishes in inducing Phase I and II enzymes in healthy male subjects (n=20). Acetaminophen is metabolized in the liver through pathways that involve Phase II enzymes, including conjugation, sulfation, and glucuronidation, that produce measurable metabolites in blood and urine. Consumption of Spanish black radishes increased liver detoxification capacity and positively altered the metabolism of acetaminophen via increased urinary excretion.4 Benefits of Glucosinolates: How Spanish Black Radish Works Spanish black radishes (Raphanus sativus l. var. niger) are particularly rich in a class of phytonutrients called glucosinolates, which have been associated with several beneficial health outcomes attributed to consumption of cruciferous vegetables.1, 2The main mechanism of action through which metabolites of glucosinolates mediate their beneficial effects may be via the induction of metabolic detoxification Phase I and II enzymes, as well as induction of antioxidant enzymes.1-5The glucosinolates in Spanish black radishes are unique in both content and concentration in comparison to other cruciferous vegetables.2 For example, the glucosinolates in Spanish black radishes make up over 4% in sprout of their total dry weight; glucosinolates in more common crucifers, such as broccoli, only constitute 1% of the broccoli sprout.2-4 In contrast to more common crucifers, >65% of the glucosinolates present in Spanish black radishes is glucoraphasatin.2 The metabolite of glucoraphasatin, 4-methylthio-3-butenyl isothiocyanate (raphasatin), carries similar potency as sulforaphane (the metabolite of glucoraphanin that is particularly abundant in broccoli) on Phase II gene expression.2,4 Metabolism of Toxins Phase I and phase II detoxification enzymes work together to help the body break down and manage compounds that need to be removed. Mice fed a diet containing 20% Spanish black radishes for two weeks showed significant enhancement of the metabolism of toxins as demonstrated by significantly increased expression of Phase I and II detoxification enzymes.5 Frequently Asked Questions What is Spanish Black Radish? Radishes (Raphanus sativus L.) are a member of the cruciferous vegetable family that contains broccoli, cauliflower, cabbage, and kale. Radishes are available in varieties that differ in terms of size, shape, and color. Spanish Black Radishes (SBR) (Raphanus sativus l. var. niger) are a variety that is particularly rich in a class of phytonutrients called glucosinolates. References: Hanlon, P.R., Barnes, D.M. (2011). J Food Sci, 76:C185. Hanlon, P.R., Webber, D.M., Barnes, D.M. (2007). J Agric Food Chem, 55:6439. Lewis, J., Fenwick, G. (1987). Food Chem, 25(4):259. Evans, M., Paterson, E., Barnes, D.M. (2014). BMC Complement Altern Med, 14:475. N’jai, A.U., et al. (2012). Nutr Canc, 64:1038. Suggested Use: One to three servings per day, or as directed. Warning: Keep out of reach of children. Nutrients & Ingredients Each Serving Size (1 Tablet) contains: Total Carbohydrate
