STAT2 Polyclonal Antibody Catalogue Numbers: BS67421-50, BS67421-100 Sizes: 50µl, 100µl Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Swiss-Prot: P52630 Host: Rabbit Reactivity: Human, Mouse, Rat, Pig Applications: WB All Applications: WB (1/500 - 1/1000) Background: Stat2 (113-kDa), originally purified from the nuclei of alpha-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta. Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via associations with receptor-bound Jak kinases. Unlike other Stat proteins, Stat2 does not form homodimers. Instead, activated Stat2 forms a heterodimer with Stat1 and translocates to the nucleus. There, it associates with the DNA-binding protein p48 and forms the transcriptional activator complex, interferon-stimulated gene factor 3 (ISGF3), promoting transcription from the ISRE. Purification and Purity: The antibody was purified by immunogen affinity chromatography. Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: Recognizes endogenous levels of STAT2 protein. Extra Notes: Western blot analysis of STAT2 expression in mouse muscle (A), rat muscle (B) whole cell lysates. Bioworld Molecular Weight: ~ 113 kDa Note: For research use only, not for use in diagnostic procedure. Alternative Name: Signal transducer and activator of transcription 2; p113 Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human STAT2. The exact sequence is proprietary. Conjugate: Unconjugated Modification: Unmodified
