Pure Encapsulations Systemic Enzyme Complex Support for Muscle, Joint, and Tissue Health This synergistic enzyme formula provides support for muscle, joint, and overall tissue health. Enzymes included in this formula have the potential to influence bradykinin formation, modulate the arachidonic cascade and prostaglandin E2 production, and provide fibrinolytic support. Proteolytic enzymes have been widely studied for their capacity to maintain healthy immune mediator activity to support muscle, cartilage, and joint health. Key Benefits and Features: Ages 18 and up Muscle, joint and tissue support Supports joint and cartilage comfort, including after exercise Promotes muscle comfort and recovery Helps maintain healthy immune mediator activity Enhanced intestinal enzyme delivery technology Contains Serrazimes®, a serrapeptidase-comparable enzyme blend Acid-resistant capsules Made with high-quality ingredients backed by verifiable science Ingredients Serving Size: 3 Vegetarian Capsules Amount/Serving Pancreatin (from porcine) (lactose-free) (50,000 USP units protease) 176 mg Protease 6.0 (60,000 HUT) 120 mg Serrazimes (protease blend) (10,000 U) 17 mg Bromelain (from pineapple stem) (2,400 GDU/g) 120 mg Papain (from papaya fruit) (800 TU/mg) 120 mg Rutin 100 mg Trypsin (from porcine) (1:150) (11,250 USP units) 75 mg Chymotrypsin (from bovine) (2,550 USP units) 3 mg Indian frankincense (Boswellia serrata) extract (gum resin) (standardized to contain 70% boswellic acids) 250 mg Other Ingredients: Vegetarian capsule (cellulose, gellan gum, water) and ascorbyl palmitate. Does Not Contain: Wheat, soy, dairy, eggs, artificial colors, artificial sweeteners, coatings, shellacs, GMOs, tree nuts, peanuts, sesame, unnecessary binders, fillers, preservatives, magnesium stearate, gluten, trans fat, and hydrogenated oils. Gluten Free, Non-GMO Suggested Use As a dietary supplement, take 3 capsules, 1-2 times daily, between meals. Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use. Storage: Store in a cool, dry place. More Info. Animal studies suggest that proteolytic enzymes may enhance muscle recovery. Positive effects on muscle comfort and recovery of contractile function were demonstrated in one placebo-controlled trial of athletes. Rutin, a natural, glycosylated derivative of the flavonoid quercetin, has exhibited superior efficacy over quercetin in animal research examining musculoskeletal and joint health. Boswellia serrata is an Ayurvedic herb that has a long history of use for connective tissue and joint support. Boswellic acids are active terpenoid constituents of Boswellia serrata that maintain healthy 5-lipoxygenase (5- LOX) enzyme activity, which is responsible for leukotriene synthesis. In addition, boswellic acids may maintain healthy human leukocyte elastase enzyme activity, preserving the integrity of healthy connective tissue. Serrazimes®, a serrapeptidase-comparable enzyme blend, maintains a healthy cytokine response. Pancreatin and trypsin are porcine-derived and lactose-free Chymotrypsin is bovine-derived and lactose-free Protease 6.0 and Serrazimes® are derived from the digestion of a nutrient source by Aspergillus oryzae and Aspergillus melleus Bromelain and papain are derived from pineapple and papaya, respectively Rutin is sourced from the Fava d’anta tree found in Brazil Boswellia serrata is standardized to contain 70% boswellic acids Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil Gellan gum is derived from Pseudomonas elodea