Specification Full name TFEB rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB Host Rabbit Clone type rabbit polyclonal Target Background Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1. Swissprot No P19484 Gene Accession BC032448 WB Predicted band size 53 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location nan IHC positive control nan IHC Recommed dilution nan Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P113966-WB-1-P
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