Ortho Molecular Thyrotain Endocrine Health Thyrotain® includes a multidimensional blend of nutrients and botanicals to help maintain healthy thyroid function. Thyrotain® is a comprehensive formulation that provides a blend of nutrients and botanicals working in synergy to support thyroid health. Thyrotain® includes L-tyrosine and iodine, which make up the backbone of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The addition of zinc, selenium, vitamin A, and the botanical guggulipid activates enzymes that enhance the conversion of T4 into the active thyroid hormone T3. Vitamin A and zinc also help improve cellular sensitivity to thyroid hormones. Turmeric, along with the antioxidants vitamin C and E and N-acetyl cysteine (NAC), provides a powerful combination of antioxidants that boost thyroid health by reducing free radical stress. Key Benefits and Features: Helps to Maintain Healthy Thyroid Function Promotes the Synthesis of Thyroid Hormones Helps Support Conversion of T4 to T3 Improves Cellular Sensitivity to Thyroid Hormones Supports a Healthy Inflammatory and Antioxidant Balance For more information, check out our blog post - Thyroid Health & Thyrotain. Ingredients Serving Size: 4 Capsules Amount/Serving Vitamin A (from 2,500 IU as Palmitate) 750 mcg Vitamin C (as Ascorbic Acid USP) 200 mg Vitamin E (from 200 IU as d-Alpha Tocopherol Succinate USP) 134 mg Iodine (from Potassium Iodide) 200 mcg Zinc (as Albion Zinc Bisglycinate Chelate) 20 mg Selenium (as SelenoExcell (a High Selenium Yeast)) 200 mcg N-Acetyl-L-Cysteine USP 500 mg L-Tyrosine USP 400 mg Ashwagandha Root Extract (standardized to contain 1.5% Withanolides) 300 mg Guggul Resin (Standardized to contain 2.5% Guggulsterones) 150 mg Turmeric Root Extract (Complete Turmeric Matrix) (Standardized to contain 45-55% Curcuminoids, 3-8% Volatile Oil, 2-6% Turmerin) 100 mg Other Ingredients: Hypromellose (Natural Vegetable Capsules), Microcrystalline Cellulose, Magnesium Stearate, Calcium Silicate, and Silicon Dioxide. Does Not Contain: Gluten, artificial colors, or flavors. Suggested Use Take 4 capsules per day or as recommended by your health care professional. Warning: Do not consume this product if you are pregnant or nursing. Consult your physician for further information. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. More Info. Vitamins and Minerals Thyroid hormones are made from the amino acid L-tyrosine and iodine. Iodine is an essential trace mineral that is necessary for the synthesis of thyroid hormones because it is one of the most important components of T4 and T3. The thyroid gland absorbs iodine from the blood and incorporates it into thyroid hormones. In addition to supporting thyroid hormone production, research shows iodine acts as an antioxidant, supporting a healthy thyroid gland and protecting a variety of tissues, including mammary tissue, the eyes, and the gastrointestinal lining. Normal thyroid status is dependent on adequate levels of many trace minerals for the synthesis and metabolism of thyroid hormones. The minerals zinc and selenium are required cofactors for the enzymes that convert T4 to T3. Selenium deficiency has been shown to contribute to decreased T4 to T3 conversion. Supplementation with selenium can also help decrease thyroperoxidase (TPO) antibodies in thyroid autoimmunity. Supplementation with zinc has been shown to restore T3 levels in patients with normal T4 and low T3, demonstrating its role in the conversion process. Vitamin A and vitamin E are also necessary for normal thyroid hormone biosynthesis. Antioxidants (Turmeric, Vitamins C and E, and N-Acetyl Cysteine) Increased free radical activity can compromise healthy T4 to T3 conversion. N-acetyl cysteine (NAC), a precursor to the body’s master antioxidant glutathione, boosts thyroid health by accelerating antioxidant activity in the thyroid gland. In a randomized, multicenter clinical trial, the effects of NAC administration were examined in patients with low T3 and high RT3 levels. RT3 decreased in a time-dependent fashion in NAC-treated patients, whereas no significant changes in serum RT3 levels were observed in the placebo group. Additionally, the T3 to RT3 ratio increased progressively in NAC-treated patients, whereas no changes were seen in the placebo group. Turmeric (the Complete Turmeric Matrix), along with the antioxidants vitamin C and E, has been shown to promote a healthy thyroid gland due to direct antioxidant activity. In animal studies, turmeric and these antioxidants were studied to observe the protective effects on thyroid health. In one study, rats that had been treated with a chemical that increased thyroid weights showed decreased T4 and T3 as compared to controls. In the treatment group, rats receiving turmeric, vitamin C, and vitamin E showed reduced weights in the thyroid gland and less suppression of T4 and T3 levels. The researchers suggested that the positive effects of the combination could be due to the direct involvement of antioxidants in the thyroid gland. The Complete Turmeric Matrix, which includes curcuminoids, volatile oils, and turmerin protein, has been shown to support the lowering of lipid peroxidation, decrease the release of reactive oxygen species,8 and significantly affect oxidative stress and immune-mediated reactions. Ashwagandha Ashwagandha (Withania somnifera) has been used in Ayurvedic and indigenous medical systems for over 3,000 years and has been examined in research studies for its stress-lowering effects. Ashwagandha has been found to exhibit GABA agonist activity, which accounts for its ability to relax the nervous system. Ashwagandha may also stimulate thyroid activity indirectly via its effects on cellular antioxidant systems, specifically by increasing the antioxidant enzymes superoxide dismutase and catalase, and reducing lipid peroxidation. In studies using mice, the effects of administration of Withania somnifera root extract (1.4 g/kg of body weight for 20 days) demonstrated an increase in serum T4 concentrations. Guggulipid (Commiphora mukul) The gum resin of the guggul plant has been used in Ayurvedic medicine in India for nearly 3,000 years. Guggulipid has been shown to support thyroid function, primarily by decreasing lipid peroxidation in the liver, the principal site of T3 generation. Guggul extract has also been shown to have thyroid-stimulating action by increasing iodine uptake by the thyroid gland and increasing the activities of thyroid peroxidase and protease. In animal studies using mice, the effects of guggulu, the gum resin of Commiphora mukul, were examined. A chemical that induced hypothyroidism was administered simultaneously, along with guggulu (200 mg/ kg of body weight per day for 30 days). In this study, it was found that treatment with guggulu decreased lipid peroxidation while increasing the activity of sodium oxidase dismutase and catalase.
