Specification Full name TMPRSS2 rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB Host Rabbit Clone type rabbit polyclonal Target Background This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Swissprot No O15393 Gene Accession BC051839 WB Predicted band size 54 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location nan IHC positive control nan IHC Recommed dilution nan Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P108793-WB-1-P
