Tocopherol necklace | sterling silver If you have ever explained antioxidant chemistry to a medical student or a curious patient, tocopherol is the molecule you reach for. Vitamin E, the chain-breaker that stops free-radical damage from propagating through cell membranes. As a 46 mm sterling silver pendant, the full structure including the chromanol head and the isoprenoid tail. The Science Behind Tocopherol Tocopherol was discovered in 1922 by Herbert Evans and Katharine Bishop at UC Berkeley, originally as a dietary factor required for rat reproduction. The name comes from the Greek tokos (childbirth) and pherein (to bear). Alpha-tocopherol is the most active form, a lipophilic molecule that sits in cell membranes and lipoprotein particles. It functions as a chain-breaking antioxidant: donating a hydrogen atom to lipid peroxyl radicals, the move interrupts the chain reaction of lipid peroxidation that would otherwise propagate through membrane phospholipids. The resulting tocopheroxyl radical is regenerated to tocopherol by ascorbate, part of an integrated cellular antioxidant network. Vitamin E supplementation for cardiovascular prevention has not held up in large randomised trials. The Audience biochemists and cell biologists studying oxidative stress nutritional scientists and clinical dietitians researchers in lipid biochemistry or membrane biology anyone drawn to the chemistry of cellular protection For someone who knows the difference between tocopherol the molecule and vitamin E the supplement. Explore Related Molecules Jewelry Tocopherol necklace | gold vermeil Anthocyanin necklace | silver Chlorophyll necklace | silver Capsaicin necklace | silver Glucose necklace | gold vermeil FAQ Why is tocopherol the antioxidant pendant rather than vitamin C or glutathione? Because tocopherol works specifically in cell membranes, where lipid peroxidation propagates through the phospholipid bilayer one chain reaction at a time. Vitamin C and glutathione are also antioxidants, but they act in the aqueous cytoplasm. Tocopherol is the lipid-soluble member of the network, the one that protects the structural fat of every cell from oxidative chain damage. That distinction is the reason it gets its own pendant. Why has vitamin E supplementation failed in clinical trials when the chemistry is solid? Because the chemistry being correct in a test tube does not predict the supplement being beneficial in a person. The body already has a coordinated antioxidant network, and dosing one component at unphysiological levels can disrupt the balance. Several large randomised trials have found no cardiovascular benefit and some signal of harm at very high doses. The molecule is real and important. The supplementation as a public-health intervention is not. What size is the pendant and what is the return policy? 925 sterling silver, 46 mm pendant on a 45 cm sterling silver chain with a 5 cm extender. The full alpha-tocopherol structure renders large because of the chromanol ring and the long isoprenoid tail. Nickel-free and hypoallergenic. Free worldwide DHL Express in 1-5 business days, with all import duties and taxes covered. 30-day “Love It or Return It” returns. Is there a gold version? Yes. The same 46 mm tocopherol pendant comes in 18K gold vermeil at the same chain length. Same molecule, different metal, different occasion.
Related
Related
Related
Related