TOPICAINE TOPICAL ANESTHETIC GEL WITH LIDOCAINE 4% PERFECT FOR USE BEFORE NEEDLE INJECTIONS TO NUMB THE AREA OF NEEDLE ENTRY. ESPECIALLY USEFUL FOR USE PRACTITIONERS WHO ARE DOING FACIAL WORK. Topicaine is a hydro-ethanolic, non-oily, translucent microemulsion gel containing lidocaine 4% with skin permeation enhancers and soothing agents, indicated as a topical anesthetic for use onnormal intact skinfor local analgesia. 10 or 30 gram tube Composition: Each gram of Topicaine contains lidocaine 40 mg in a gel composed of water, ethanol (35% w/w), glycerin, jojoba oil, aloe vera oil, glyceryl monolaurate, benzyl alcohol, carbomer 940, EDTA. Topicaine has a pH of 7.5 Action: Topicaine applied to intact skin provides dermal analgesia by the release of lidocaine from the gel into the epidermis and dermis. Lidocaine is a local anesthetic agent of the amide type. Local anesthetics reversibly block the initiation and conduction of nerve impulses by interfering with the flux of sodium ions though the neuronal membrane. The onset, depth and duration of dermal analgesia provided by Topicaine�depend primarily on the site of application and duration of application. Adequate dermal analgesia is obtained after 1 hour of application, and the effect persists for approximately 1 hour after removal. Areas such as the upper lip may be numb after 30 minutes of application. Dermal application of Topicaine�may cause local blanching followed by local redness or erythema. These effects are mild and transitory. Useage: Topicaine(lidocaine 4%) is indicated for the temporary relief of pain and itching. It is a topical analgesic for use onnormal intact skinfor local pain relief. Topicaine is not recommended for use on mucous membranes because of much greater absorption than through intact skin. Topicaine is not recommended for use beyond the external ear. Not for ophtalmic use. Warnings: For external use only. Avoid contact with the eyes. Do not use over large areas of the body. Do not use for more than 7 days unless directed by a doctor. Keep this and all drugs out of the reach of children. In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately. Inappropriate use of this product, such as application on mucous membranes, on large areas of the body, or on individuals that are allergic to the amide type anesthetics, may result in serious side effects. Consultation with a doctor before using this product is strongly recommended. Repeated doses of Topicaine may increase blood levels of lidocaine. Avoid contact with the eye since it may cause severe irritation and loss of protective reflexes. If eye contact occurs, immediately wash out the eye with water or saline. Patients with severe hepatic disease are at a greater risk of developing toxic plasma concentrations of lidocaine. Drug Interactions: Topicaine should be used with caution in patients receiving Class I antiarrythmic agents (such as tocainide and mexiletine) since the toxic effects are additive and potentially synergistic
