Biological Age Score: OMICmAge (Multi-Omic Methylation Age) The OMICmAge is a state-of-the-art epigenetic clock trained on over 1.1 million CpG sites across the genome, integrating DNA methylation with multi-omic data layers (transcriptomics, proteomics, and clinical biomarkers) for superior accuracy. Algorithm: Trained on 13,661 diverse samples with causal and predictive machine learning models Correlation with chronological age: r = 0.97 (outperforms Horvath, Hannum, PhenoAge, and GrimAge) Mean Absolute Error (MAE): 2.7 years – the lowest error rate among commercial epigenetic clocks Biological relevance: Captures mitochondrial function, inflammation, immune senescence, and metabolic efficiency Clinical Applications: Identify patients ageing faster than chronological age (high OMICmAge delta) Track reversal potential – average 1.5–3 year reduction in OMICmAge after 6 months of optimised protocols Benchmark against population norms (50th, 75th, 90th percentiles provided) “OMICmAge is the first clock to integrate causal omics data, making it uniquely responsive to interventions.”Dr. Kara Fitzgerald, Epigenetics Researcher Grip Strength & Gait Speed (Functional Age Markers) Predicted from epigenetic data (no equipment needed) Validated against NIH Toolbox norms Flags sarcopenia risk 5–10 years early DunedinPACE – Pace of Aging Measures rate of aging (not just state) 1.0 = average (1 year older per chronological year)
