Supplement Facts & Directions Supplement Facts Serving Size: 500 milligrams Servings Per Container: Varies Amount Per Serving % Daily Value* Varuna Extract (Crataeva nurvala) (Bark) 450 mg (Standardized to 10% Saponins) † * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive. Please call for exact numbers. Supplement Facts Serving Size: 1 Capsule Servings Per Container: Varies Amount Per Serving % Daily Value* Varuna Extract (Crataeva nurvala) (Bark) 450 mg (Standardized to 10% Saponins) † * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive. Please call for exact numbers. Supplement Facts Serving Size: 1 Capsule Servings Per Container: Varies Amount Per Serving % Daily Value* Varuna Extract (Crataeva nurvala) (Bark) 450 mg (Standardized to 10% Saponins) † * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive. Please call for exact numbers. Other Ingredients: ≤10% Maltodextrin Contains: Free of: Added Sugar, Soy, Dairy, Yeast & Gluten. Directions: As a dietary supplement, take 500 mg (1/8 tsp) twice daily or as directed by a physician. Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Other Ingredients: Cellulose Capsule, ≤10% Maltodextrin Contains: Free of: Added Sugar, Soy, Dairy, Yeast & Gluten. Directions: As a dietary supplement, take one capsule twice daily or as directed by a physician. Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Other Ingredients: Gelatin Capsule (Bovine Source), ≤10% Maltodextrin Contains: Free of: Added Sugar, Soy, Dairy, Yeast & Gluten. Directions: As a dietary supplement, take one capsule twice daily or as directed by a physician. Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Product Details What is Varuna Bark Extract? Varuna Bark Extract is derived from the bark of the Crataeva nurvala tree (also known as Crateva magna). It is native to regions of South Asia, including India and Sri Lanka. The Varuna tree has deep roots in Ayurvedic cultures, which have utilized the tree’s bark for centuries. In Sanskrit, "Varuna" refers to the deity of water, reflecting the plant's historical connection to supporting urinary and kidney health in holistic remedies. Traditional Ayurvedic texts describe Varuna as a plant used to balance the doshas—Vata, Pitta, and Kapha—especially when associated with the body's fluid regulation. Beyond its historical significance, researchers continue to study Varuna bark extract for its bioactive compounds and potential wellness applications. Varuna tree bark contains several notable phytochemicals that contribute to its traditional uses and benefits. These include: Tannins – Known for their astringent properties, tannins support tissue health and help protect cells from oxidative stress. Flavonoids – These antioxidants neutralize free radicals, reduce oxidative damage, and support overall cellular health. Saponins – Saponin compounds have natural surfactant properties. They support healthy lipid metabolism, digestion, and fluid balance. Alkaloids – Active constituents with a range of biological activities, including supporting the normal function of smooth muscles in the urinary and gastrointestinal systems. Lupeol – A triterpenoid known for its potential antioxidant, anti-inflammatory, hepatoprotective, and nephroprotective properties. Sterols – Plant sterols such as -sitosterol are thought to support urinary health and overall well-being. Potential Varuna Bark Extract Benefits Supports Kidney and Urinary Health Traditional ayurvedic remedies use Varuna Bark Extract to promote healthy kidney and urinary tract function. Its phytochemicals, such as flavonoids and tannins, support normal diuresis and the body's natural detoxification processes. Mechanistically, research shows that these compounds exert a mild diuretic effect, facilitating the expulsion of excess fluids and helping to alleviate minor urinary discomfort. Emerging studies also highlight the extract's potential to inhibit kidney stone formation. Its diuretic properties help flush out excess minerals and waste products from the body that can contribute to stone formation. Varuna bark also has antioxidant and anti-inflammatory properties that can reduce the oxidative stress and ensuing inflammation that promote kidney stone development. Research also shows that Varuna bark compounds, particularly lupeol, interfere with the crystallization process that forms kidney stones. Antioxidant Properties Varuna bark extract is rich in antioxidants, such as flavonoids, tannins, and triterpenoids. These compounds help protect the body from oxidative stress. Oxidative stress occurs when there is an imbalance between free radicals and the body's ability to neutralize them, potentially leading to cellular damage. Research shows that Varuna bark’s antioxidants scavenge free radicals, reducing oxidative tissue damage. These properties may support overall cellular health and resilience, particularly in organs susceptible to oxidative stress, such as the liver and kidneys. Digestive Support Traditionally, Ayurvedic remedies used Varuna bark to support digestive health by promoting balanced gastrointestinal function. Ayurveda suggests that Varuna can help enhance digestive fire, or "Agni," which is essential for efficient digestion and nutrient absorption. It may also help relieve gastric irritation. Research shows that phytochemicals like saponins help maintain the mucosal lining of the stomach and intestines, contributing to a healthy gastrointestinal environment. Additionally, the extract may provide relief from diarrhea by slowing down the intestines and regulating fluid loss, thanks to the presence of certain chemicals within it, particularly flavonoids. Anti-Inflammatory Properties Varuna bark extract’s bioactive compounds have demonstrated anti-inflammatory properties in various studies. These phytochemicals work by modulating the production of pro-inflammatory mediators, such as cytokines and enzymes, which play a role in the body’s inflammatory pathways. Varuna bark may help maintain tissue health and minimize discomfort associated with occasional inflammation by reducing the activity of these mediators. Potential Varuna Bark Extract Side Effects Varuna bark extract is generally safe when used in appropriate amounts. However, some individuals may experience mild gastrointestinal discomfort, such as nausea or cramping, particularly if taken on an empty stomach. Due to its diuretic properties, Varuna bark extract may influenc References https://pubmed.ncbi.nlm.nih.gov/33514941 https://pmc.ncbi.nlm.nih.gov/articles/PMC8591093 https://pmc.ncbi.nlm.nih.gov/articles/PMC10432060 https://pmc.ncbi.nlm.nih.gov/articles/PMC6194725 https://pmc.ncbi.nlm.nih.gov/articles/PMC3221072 https://fjps.springeropen.com/articles/10.1186/s43094-020-00106-1 https://pubmed.ncbi.nlm.nih.gov/10704264 https://rjpponline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacognosy%20and%20Phytochemistry;PID=2010-2-4-5 https://pmc.ncbi.nlm.nih.gov/articles/PMC10654971 https://www.tandfonline.com/doi/abs/10.1080/10496470802341532 https://www.sciencedirect.com/science/article/abs/pii/S0963996921001630 https://thematicsjournals.org/index.php/think-india/article/view/12805/8078 https://pmc.ncbi.nlm.nih.gov/articles/PMC4081679 https://pubmed.ncbi.nlm.nih.gov/30105414 https://pmc.ncbi.nlm.nih.gov/articles/PMC11124185 https://www.innovareacademics.in/journal/ijpps/Vol2Suppl1/497.pdf https://pmc.ncbi.nlm.nih.gov/articles/PMC11174216 Tested by Accredited 3rd Party Labs PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity, and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here. *NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
