60 Capsules (30-day supply) Helps Promote Normal Lymphatic Drainage* Supports Antioxidant Activity* Supports Blood Glucose Metabolism* Supports Healthy Eicosanoid Metabolism* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Vein Support Formula: Overview Doctor Emi's Vein Support Formula contains well-researched, citrus-based flavonoids in a unique micronized form for enhanced absorption and bioavailability. Research suggests that these compounds support healthy veins, capillaries, and blood flow; promote healthy lymphatic drainage; and enhance antioxidant activity; and support healthy eicosanoid metabolism. More recent research suggests that the components in Vein Support Formula also support blood glucose metabolism.* Non-GMO Soy-Free Gluten-Free Made in the USA Manufactured in a GMP Compliant Facility DOES NOT CONTAIN: wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Vein Support Formula: Directions Take one capsule twice daily, or as directed by your healthcare practitioner.Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged. Vein Support Formula: Other Ingredients HPMC (capsule), dicalcium phosphate dihydrate, stearic acid, magnesium stearate, microcrystalline cellulose, silica, and medium-chain triglyceride oil. Vein Support Formula: Storage Keep closed in a cool, dry place out of reach of children. Vein Support Formula: In-Depth Information Diosmin is a well-researched citrus flavonoid that has been utilized for decades to support healthy capillary and vein function as well as healthy microcirculation throughout the body. Diosmin fundamentally helps maintain the structure and function of the circulatory system, especially vein strength and competence.[1] The most promising research results come from a micronized purified flavonoid fraction comprising 450 mg of diosmin and 50 mg of hesperidin (hesperidin is a precursor to diosmin). This is the same ratio and dose found in each Vein Support Formula capsule. The process of micronization (reducing particle size to less than two micrometers in diameter) improves diosmin absorption.*[2] Micronized purified flavonoid fraction (MPFF) appears to support vein health by prolonging the normal effect that the catecholamine norepinephrine has on the vessel wall; and this, therefore, promotes venous tone.[3] Research also suggests that MPFF affects the synthesis of prostaglandins and free radicals, as well as leukocyte activation, trapping, and migration. Ultimately, MPFF supports antioxidant systems and eicosanoid balance.*[4-7] Pharmacological and clinical studies suggest that MPFF—on its own and in conjunction with standard therapy—promotes normal lymph drainage, healthy capillary permeability, and favorable microcirculation. Multicenter, prospective, randomized, controlled studies document the effect of MPFF on maintaining healthy venous sufficiency.[8] Two randomized, double-blind, placebo-controlled studies conducted over a two-month period demonstrated the venotropic nature of Vein Support Formula's main component. Significant support of organic and functional parameters occurred along with significant support of venous hemodynamics.[9] Some studies indicate that favorable results can be achieved within two hours of administration.*[10] A review of the literature suggests that health-related quality-of-life parameters were found to improve with the use of MPFF and were associated with the formula’s support of microcirculation and vein function.[2] A singlecenter, double-blind, placebo-controlled study suggested that MPFF had a positive and protective effect on five study variables (red blood cell aggregation, red blood count, microcirculatory blood flux, and amplitude and frequency of vasomotion).[11] A double-blind placebo-controlled trial of MPFF over a six-week period suggested that the formula, administered twice daily, significantly (p