MMAE, or monomethyl auristatin E, is a potent cytotoxic agent commonly used in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is an antimitotic agent which inhibits cell division by blocking the polymerization of tubulin. Specifications Cat.No. 31903ES60/31903ES80 Size 100 μg/1 mg Source Monoclonal anti-MMAE antibody, is produced from a hybridoma which was obtained from a mouse immunized with MMAE. Buffer 1×PBS, pH7.4. Type Monoclonal Antibody Isotype IgG1 Host Mouse Concentration 1 mg/mL Purity ＞94% as determined by reduced SDS-PAGE ＞97% as determined by non-reduced SDS-PAGE > 98% as determined by SEC-HPLC Activity EC50=6.3 ng/mL by ELISA Application ELISA Storage This product should be stored at -25~-15℃ for one year, do not freeze. Notes This product is for research use only. Please operate with lab coats and disposable gloves, for your safety. Data SDS-PAGE Anti-MMAE mouse mAb on SDS-PAGE under reduced condition. The purity is 94.7%； Anti-MMAE mouse mAb on SDS-PAGE under non-reduced condition. The purity is 97.6%. SEC-HPLC The purity of Anti-MMAE mouse mAb is 98% as determined by SEC-HPLC. ELISA Data Dose response curve shows that the EC50 of Anti-MMAE mouse mAb is 6.3 ng/mL.
