SN38 is the active metabolite of the chemotherapy drug irinotecan (Camptosar). It is a topoisomerase I inhibitor, prevents the enzyme from properly resealing the DNA strands after they have been unwound, which leads to the accumulation of DNA damage. Specifications Cat.No. 31905ES60/31905ES80 Size 100 μg/1 mg Source Monoclonal anti-SN38 antibody, is produced from a hybridoma which was obtained from a mouse immunized with SN38. Buffer 1×PBS, pH7.4. Type Monoclonal Antibody Isotype IgG1 Host Mouse Concentration 1 mg/mL Purity ＞95% as determined by reduced SDS-PAGE ＞99% as determined by non-reduced SDS-PAGE > 99% as determined by SEC-HPLC Activity EC50=80.5 ng/mL by ELISA Application ELISA Storage This product should be stored at -25~-15℃ for one year, do not freeze. Notes This product is for research use only. Please operate with lab coats and disposable gloves, for your safety. Data SDS-PAGE Anti-SN-38 mouse mAb on SDS-PAGE under reduced condition. The purity is 95.5%； Anti-SN-38 mouse mAb on SDS-PAGE under non-reduced condition. The purity is 99.2%. SEC-HPLC The purity of Anti-SN-38 mouse mAb is 100% as determined by SEC-HPLC. ELISA Data Dose response curve shows that the EC50 of Anti-SN-38 mouse mAb is 80.5 ng/mL.
