IL-1 α and IL-1 β are potent pro-inflammatory cytokines that induce multiple biological activities in different cell types. Two different types of IL-1 receptors have been identified and cloned from human and mouse cells. IL-1 receptor type I is an 80 kDa transmembrane protein with a demonstrated IL-1 signaling function, while IL-1 receptor type II is a 68 kDa membrane protein with a relatively short cytoplasmic tail and no signaling function. The type II receptor acts as a decoy target for IL-1, inhibiting IL-1 activity by preventing IL-1 from binding to the type I receptor.The soluble version of the type II receptor is induced by anti-inflammatory agents (e.g., glucocorticoids, IL-4, and IL-13). This product is available as Liquid, high activity, high purity, low endotoxin, No labeling. Product Properties Synonyms IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL1F1; IL-1F1; IL1F1hematopoietin-1; interleukin 1, alpha; interleukin-1 alpha; LAF; LEM; preinterleukin 1 alpha; pro-interleukin-1-alpha Species Mouse Source HEK293 Ceslls Sequence Ser6-Ser161 Accession P01582 Tag No Predicted molecularmass 18.0 KDa Endotoxin 95%, determined by SDS-PAGE Activity Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The EC50 for this effect is 3-7 pg/mL. Formulation Dissolved in sterile PBS buffer. Appearance Liquid Shipping and Storage -85~-65℃ storage, valid for 1 year after receipt. Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃. Cautions 1. For your safety and health, please wear lab coat and disposable gloves. 2. This product is for scientific research purposes only.
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