Biotinylated Mouse CD7 Protein, hFc Tag

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CD7, also known as Leu-9, is an approximately 40 kDa glycosylated and palmitoylated transmembrane protein in the immunoglobulin superfamily. Mature human CD7 consists of a 155 amin o acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 39 aa cytoplasmic domain. Within the ECD, human CD7 shares 43% and 41% aa sequence identity with mouse and rat CD7, respectively. CD7 is expressed on T cells, NK cells, myeloid progenitor cells, and CD19+ B progenitor cells. Among CD8+ T cells, the CD7-bright population preferentially contains naïve and memory cells, while more weak expressors are primarily effector cells. It also enhances integrin-mediated adhesion of these cells to Fibronectin, ICAM-1, and VCAM-1 . CD7 additionally mediates the Galectin-1 induced apoptosis of T cells and facilitates the fusion of HIV-1 with target cells. Specifications Synonyms CD7 molecule; CD7; LEU-9; Tp40; TP41; GP40 Uniprot No. P50283 Source Recombinant Biotinylated Mouse CD7 Protein is expressed from HEK293 Cells with hFc tag at the C-terminal. It contains Gln24-Pro150. Molecular Weight The protein has a predicted MW of 41 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Tris-Bis PAGE result. Physical Appearance Liquid Solution Purity > 95% as determined by SDS-PAGE and HPLC Endotoxin < 1.0 EU per 1 μg of the protein by the LAL method. Formulation Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Storage The products are shipped with ice pack and can be stored at -80°C for 1 year. Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles. Note 1.For your safety and health, please wear lab coats and disposable gloves for operation. 2.For research use only! Product Data Show more