Biotinylated Rhesus macaque CD5 Protein, His-Avi Tag

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CD5, also known as Leu-1, Ly-1, and T1, is a 67 kDa transmembrane glycoprotein in the scavenger receptor superfamily. CD5 has been shown to interact homophilically, with CD72 on B cells, and with beta-glucan components of fungal cell walls. CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor (TCR) and is upregulated on tolerized peripheral CD4+ cells. It inhibits TCR signaling and promotes T cell nonresponsiveness and survival. CD5 signaling inhibits the generation of regulatory T cells but promotes the development of Th17 cells. Within the B cell lineage, CD5 is expressed on B-1a cells, anergic B cells, and IL-10 producing regulatory B cells. CD5 is also involved in the cellular entry of hepatitis C virus into T cells. Specifications Synonyms CD5 molecule; CD5; LEU1; T1; CD5 antigen Uniprot No. F6V5Q9 Source Recombinant Biotinylated Rhesus macaque CD5 Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Arg25-Pro375. Molecular Weight The protein has a predicted MW of 41.7 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result. Physical Appearance Liquid Solution Purity > 95% as determined by SDS-PAGE and HPLC Endotoxin < 1.0 EU per 1 μg of the protein by the LAL method. Formulation Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Storage The products are shipped with ice pack and can be stored at -80°C for 1 year. Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles. Note 1.For your safety and health, please wear lab coats and disposable gloves for operation. 2.For research use only! Product Data Show more