Although everyone loses bone density as they age, certain groups are particularly at risk. As many as half of all women in the United States older than 65 should be concerned about maintaining good bone health. Thorne's Advanced Bone Support is a comprehensive bone support supplement.* It contains dicalcium malate and dimagnesium malate (two calcium or magnesium molecules each bound to one molecule of malic acid) for enhanced absorption and greater concentration of these important minerals.*Adequate magnesium intake promotes bone density by optimizing the secretion of parathyroid hormone and facilitating active calcium transport to the bones.* Advanced Bone Support provides vitamin D3, which facilitates the absorption of calcium; boron, which assists the body's metabolism of vitamin D and estrogen; and B vitamins for healthy methylation, which mediates homocysteine levels, a known risk factor of low bone density.*Research indicates that an elevated homocysteine level in the blood can interfere with the integrity of the bone matrix. Therefore, Advanced Bone Support contains methylcobalamin (an active form of vitamin B12), L-5-methyltetrahydrofolate (the active form of folic acid), and pyridoxal 5'-phosphate (the active form of vitamin B6) for their function in helping to maintain already normal homocysteine levels.* To provide a bone health formula that can be used by individuals taking a blood-thinning medication, Advanced Bone Support does not contain vitamin K.As women age, they experience an overall increase in bone loss compared to bone formation, so a woman's concern about maintaining good bone health should begin well before menopause. Because some bone loss during menopause is inevitable, more bone a woman has "banked" earlier in life, the greater her peak bone mass as she begins to age. Hence, menopausal bone loss will have less of an adverse impact. Even women in the 18-35 year-old age group should make an effort to achieve good bone health, because physical inactivity, low body weight, eating disorders, and poor nutrition during these ages can have adverse impacts on bone health later in life.Groups at particular risk for bone loss in addition to women include smokers, those with a sedentary lifestyle, individuals who consume excessive sugar, alcohol, or caffeine, small-boned individuals, Caucasians, Asians, and patients on steroid or anticonvulsant therapies for prolonged periods of time.Suggested Use:Take 2 capsules two times daily or as recommended by your health-care practitioner.Warnings:ALLERGY WARNINGThis product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.PREGNANCYIf pregnant, consult your health-care practitioner before using this product.INTERACTIONS5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
