What it is: Auto Immune 1™ is a six-ingredient botanical formula from Panaxea International supporting immune regulation, Th1/Th2 cytokine rebalancing, IL-10 promotion, and chronic inflammatory burden reduction. The formula has no known contraindications, making it well-suited for complex multi-medication clinical presentations. Manufactured to Australian Pharmaceutical GMP standards for exclusive practitioner-directed use. How it works: Salvia miltiorrhiza (Tanshinone II-A) suppresses IL-12 production in activated macrophages and IFN-γ in primed lymphocytes — directly targeting the Th1 polarization signal at the transcriptional level. Trichosanthes root (Trichosanthin) promotes IL-10 output and suppresses TNF-α and IFN-γ, supporting T-regulatory cell activity characteristically deficient in autoimmune conditions. Caesalpinia sappan (Brazilin) inhibits NF-κB nuclear translocation and suppresses T-cell proliferation and pro-inflammatory cytokine production. Sedum acre contributes the formula's highest botanical dose with broad anti-inflammatory, antioxidant, and lymphatic circulatory support. Cuscuta racemosa flavones provide immunomodulatory and adrenal-supportive activity. Portulaca oleracea supports hepatoprotection and systemic inflammatory burden reduction. When to use it: Indicated for adults with autoimmune conditions, chronic inflammatory disease, or Th1-dominant immune dysregulation. Two to three capsules two to three times daily, titrated to response. No known contraindications or drug interactions — suitable for use alongside concurrent medications under appropriate clinical oversight.