Barrier Topical Solution for Dogs, 55.1-88 lbs, (Blue)

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Monthly 6-in-1 Spot-On for Heartworm, Fleas and Parasites in Large Dogs Product Description Barrier Topical Solution (Blue Box, 55.1 to 88 lbs) is an FDA-approved, prescription-onl y monthly spot-on for dogs and puppies 7 weeks+ weighing 55.1 to 88 lbs. Each 4.0 mL tube delivers 10% imidacloprid and 2.5% moxidectin, the same active ingredients as Advantage Multi for Dogs. One monthly dose prevents heartworm, treats microfilariae, kills adult fleas, treats intestinal worms, and controls sarcoptic mange in large dogs. Benefits Prevents Heartworm Disease: Moxidectin prevents Dirofilaria immitis larval development into adult heartworms when applied once monthly to large dogs. Treats Circulating Microfilariae: Unlike many other preventives, Barrier for Dogs also treats existing Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills Adult Fleas: Imidacloprid kills adult fleas fast, providing effective flea treatment and preventing flea infestations with each monthly dose. Treats Intestinal Worms: Effectively treats and controls intestinal infections caused by hookworms, roundworms, and whipworms in large dogs. Treats Sarcoptic Mange: Treats and controls sarcoptic mange (Sarcoptes scabiei) infestations in large dogs with each monthly topical application. Higher Moxidectin Concentration: Contains 2.5% moxidectin, significantly higher than the cat formulation, providing the dose required for large dogs. Same Ingredients, Better Value: Contains the same active ingredients as Advantage Multi for Dogs, offering equivalent six-in-one parasite protection. Made in the USA: Manufactured and packaged in the USA from a registered FDA facility, ensuring quality and regulatory compliance. Ingredients Composition Table Ingredient Quantity Imidacloprid 10% (400 mg per 4.0 mL tube) Moxidectin 2.5% (100 mg per 4.0 mL tube) Other Ingredients Benzyl alcohol, Propylene carbonate How to Use Directions for Use Prescription Required: This product is restricted by U.S. law to use only under the order of a licensed veterinarian. Dog Must Be Standing: Have your large dog standing throughout the entire application process to ensure even solution distribution. Open the Tube Correctly: Keep the tube upright, turn the cap to open the seal, and leave the cap on during application. Apply Along the Backline: Part the hair and apply the entire contents at 3 to 4 spots along the top of the backline from the neck. Squeeze Entire Contents: Apply directly onto the skin at each spot and allow the area to dry naturally without rubbing the product in. Lift Tube Before Releasing: Remove the tube from the skin before releasing pressure to prevent the solution from being drawn back in. Apply Once Monthly: Administer every 30 days for continuous heartworm prevention, flea control, and parasite protection throughout the year. Prevent Post-Application Licking: Keep the dog from licking application sites for 30 minutes and separate treated animals from other pets. Test for Heartworm First: Test all dogs for existing heartworm infection before starting Barrier; consult your veterinarian about adulticide treatment if needed. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Minimum Age and Weight: Not suitable for dogs that are under 7 weeks old or weigh less than 3 pounds. Never Use on Cats: This dog formulation contains 2.5% moxidectin, far higher than the cat formula, and can be fatal to cats. Do Not Give Orally: Never administer this product orally; ingestion may cause depression, salivation, dilated pupils, incoordination, panting, and muscle tremors. Avermectin-Sensitive Dogs: In MDR1-mutation dogs, accidental oral ingestion may cause severe reactions including coma and death; use with extreme caution. Sick or Debilitated Dogs: Use with caution in sick, debilitated, or underweight animals and always seek veterinary guidance before applying Barrier. Breeding, Pregnant, Lactating Dogs: Safety has not been established in breeding, pregnant, or lactating dogs; consult your veterinarian before use. Keep Children Away: Children should not come into contact with the application sites for two hours after applying the product. Eye Irritant for Humans: Rinse eyes with water for 15 minutes if exposed, and be sure to wash hands carefully with soap and water after handling. Possible Side Effects Hematochezia and Diarrhea: Blood in stool and diarrhea have been reported in field studies; contact your veterinarian if these occur. Vomiting and Inappetence: Vomiting and reduced appetite have been reported following treatment in field safety studies with dogs. Lethargy and Pyoderma: Lethargy and skin infection at the application site have been reported in dogs during field studies. Neurological Signs: Weakness, depression, and unsteadiness have been reported in dogs after application; contact your veterinarian immediately if observed. Application Site Reactions: Localized itching and hyperkeratosis at the application site have been reported in dogs with pre-existing flea allergy dermatitis. Storage Information Store at Cool Temperature: Store between 4°C (39°F) and 25°C (77°F); avoid exposure to excess heat or cold at all times. Secure Storage Required: Store this prescription product securely out of reach of children and other animals at all times. Shipping & Return We offer ground, express, and priority delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What does Barrier Topical Solution (Blue Box) treat and prevent in large dogs? Ans: Barrier Blue Box for dogs 55.1 to 88 lbs is a monthly 6-in-1 spot-on that prevents heartworm, treats circulating microfilariae, kills adult fleas, treats flea infestations, controls hookworms, roundworms, and whipworms, and treats sarcoptic mange in dogs and puppies 7 weeks or older. Q2: How does the Blue Box differ from the Yellow Box for large dogs? Ans: The Blue Box contains 4.0 mL delivering 400 mg imidacloprid and 100 mg moxidectin for dogs weighing 55.1 to 88 lbs. The Yellow Box contains 5.0 mL delivering 500 mg imidacloprid and 125 mg moxidectin for dogs 88.1 to 110 lbs. Both provide identical six-in-one protection. Q3: Can the Blue Box large dog spot-on treat a heartworm-positive dog? Ans: Yes. Barrier for Dogs is indicated for treating Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. It does not eliminate adult heartworms, so veterinarians may also recommend adulticide treatment to remove existing adult worms alongside the microfilariae treatment protocol. Q4: Why must the Blue Box dog formula never be used on cats? Ans: Barrier for Dogs contains 2.5% moxidectin, more than double the cat formulation's 1% concentration. Applying it to a cat delivers a dangerous overdose that can be fatal. The dog and cat formulations are never interchangeable under any circumstances. Q5: Is the large dog monthly spot-on safe for pregnant or lactating dogs? Ans: Safety has not been established for use in breeding, pregnant, or lactating dogs. If your large dog is pregnant, nursing, or intended for breeding, always consult your veterinarian before starting any parasite prevention program to determine the safest and most appropriate option. Clinical Research Imidacloprid – NPIC (National Pesticide Information Center) Dirofilaria immitis (Heartworm) – University of Saskatchewan (WCVM) Moxidectin – ScienceDirect Sarcoptic Mange – VCA Animal Hospitals Show more