Monthly 6-in-1 Spot-On for Heartworm, Fleas and Parasites in Large Dogs Product Description Barrier Topical Solution (88.1 to 110 lbs) is an FDA-approved, prescription-only monthly spot-on for dogs and puppies 7 weeks or older weighing 88.1 to 110 lbs. Each 5 mL tube delivers 10% imidacloprid and 2.5% moxidectin, the same active ingredients as Advantage Multi for Dogs. One monthly dose prevents heartworm, treats microfilariae, kills adult fleas, treats intestinal worms, and controls sarcoptic mange in large dogs. Benefits Prevents Heartworm Disease: Moxidectin prevents Dirofilaria immitis larval development into adult heartworms when applied once monthly to large dogs. Treats Circulating Microfilariae: Unlike many preventives, Barrier for Dogs also treats existing Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Kills Adult Fleas: Imidacloprid kills adult fleas fast, providing effective flea treatment and preventing flea infestations with each monthly dose. Treats Intestinal Worms: Effectively treats and controls intestinal infections caused by hookworms, roundworms, and whipworms in large dogs. Treats Sarcoptic Mange: Treats and controls sarcoptic mange (Sarcoptes scabiei) infestations in large dogs with each monthly topical application. Higher Moxidectin Concentration: Contains 2.5% moxidectin, significantly higher than the cat formulation, providing the dose required for large dogs. Same Ingredients, Better Value: Contains the same active ingredients as Advantage Multi for Dogs, offering equivalent six-in-one parasite protection. Made in the USA: Manufactured and packaged in the USA from a registered FDA facility, ensuring quality and regulatory compliance. Ingredients Composition Table Ingredient Quantity Imidacloprid 10% (500 mg per 5.0 mL tube) Moxidectin 2.5% (125 mg per 5.0 mL tube) Other Ingredients Benzyl alcohol, Propylene carbonate How to Use Directions for Use Prescription Required: Federal law in the US permits use of this medicine only as directed by a licensed veterinarian. Dog Must Be Standing: Have your large dog standing throughout the entire application process to ensure even solution distribution. Open the Tube Correctly: Position the tube vertically, turn the cap to break the seal, and apply without removing the cap. Apply Along the Backline: Part the hair and apply the entire contents at 3 to 4 spots along the top of the backline from the neck. Squeeze Entire Contents: Apply directly onto the skin at each spot and allow the area to dry naturally without rubbing the product in. Lift Tube Before Releasing: Remove the tube from the skin before releasing pressure to prevent the solution from being drawn back in. Apply Once Monthly: Administer every 30 days for continuous heartworm prevention, flea control, and parasite protection throughout the year. Prevent Post-Application Licking: Keep the dog from licking application sites for 30 minutes and separate treated animals from other pets. Test for Heartworm First: Test all dogs for existing heartworm infection before starting Barrier; consult your veterinarian about adulticide treatment if needed. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Minimum Age and Weight: Not suitable for dogs younger than 7 weeks or lighter than 3 lbs. Never Use on Cats: This dog formulation contains 2.5% moxidectin, far higher than the cat formula, and can be fatal to cats. Do Not Give Orally: Never administer this product orally; ingestion may cause depression, salivation, dilated pupils, incoordination, panting, and muscle tremors. Avermectin-Sensitive Dogs: In MDR1-mutation dogs, accidental oral ingestion may cause severe reactions including coma and death; use with extreme caution. Sick or Debilitated Dogs: Use with caution in sick, debilitated, or underweight animals and always seek veterinary guidance before applying Barrier. Breeding, Pregnant, Lactating Dogs: Safety has not been established in breeding, pregnant, or lactating dogs; consult your veterinarian before use. Keep Children Away: Children should not come into contact with the application sites for two hours after applying the product. Eye Irritant for Humans: Rinse eyes with water for 15 minutes if exposure happens, and make sure to wash hands properly with soap and water afterward. Possible Side Effects Hematochezia and Diarrhea: Blood in stool and diarrhea have been reported in field studies; contact your veterinarian if these occur. Vomiting and Inappetence: Vomiting and reduced appetite have been reported following treatment in field safety studies with dogs. Lethargy and Pyoderma: Lethargy and skin infection at the application site have been reported in dogs during field studies. Neurological Signs: Weakness, depression, and unsteadiness have been reported in dogs after application; contact your veterinarian immediately if observed. Application Site Reactions: Localized itching and hyperkeratosis at the application site have been reported in dogs with pre-existing flea allergy dermatitis. Storage Information Store at Cool Temperature: Store between 4°C (39°F) and 25°C (77°F); avoid exposure to excess heat or cold at all times. Secure Storage Required: Store this prescription product securely out of reach of children and other animals at all times. Shipping & Return We offer ground, express, and priority delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What does Barrier Topical Solution (88.1 to 110 lbs) treat in large dogs? Ans: Barrier for Large Dogs is a once-a-month topical treatment that protects dogs 7 weeks and older by preventing heartworm, killing adult fleas, treating flea infestations, addressing circulating microfilariae, and controlling hookworms, roundworms, whipworms, and sarcoptic mange. Q2: Can the large dog heartworm spot-on be used on dogs over 110 lbs? Ans: For dogs over 110 lbs, the appropriate combination of Barrier tube sizes should be used to achieve the correct total dose of 4.5 mg/lb imidacloprid and 1.1 mg/lb moxidectin, as directed by your veterinarian. Never rely on a single 88.1 to 110 lbs tube alone. Q3: Can Barrier for Dogs treat a heartworm-positive dog? Ans: Yes. Barrier for Dogs is indicated for the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. It does not eliminate adult heartworms, so veterinarians may also recommend adulticide treatment to remove existing adult worms alongside the microfilariae treatment protocol. Q4: Is the large dog monthly spot-on safe for herding or avermectin-sensitive breeds? Ans: Barrier contains moxidectin, a macrocyclic lactone similar to ivermectin. In avermectin-sensitive breeds carrying the MDR1 gene mutation, such as Collies and Australian Shepherds, accidental oral ingestion can cause severe reactions including coma and death. Always consult your veterinarian before use in herding breeds. Q5: How does the large dog spot-on compare to Advantage Multi for Dogs? Ans: Barrier for Dogs and Advantage Multi for Dogs contain identical active ingredients, 10% imidacloprid and 2.5% moxidectin, at the same concentrations, providing equivalent six-in-one parasite protection. Both are FDA-approved monthly prescription topicals, with the primary difference being the brand name and price point. Imidacloprid – NPIC (National Pesticide Information Center) Dirofilaria immitis (Heartworm) – University of Saskatchewan (WCVM) Moxidectin – ScienceDirect Sarcoptic Mange – VCA Animal Hospitals
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