Specification Full name FADD rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB, IHC Host Rabbit Clone type rabbit polyclonal Target Background The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. Swissprot No Q13158 Gene Accession BC000334 WB Predicted band size 23 kDa WB Positive control WB Recommended dilution 1000-5000 IHC predicted cell location Predicted cell location: Cytoplasm IHC positive control Positive control: Human colon cancer IHC Recommed dilution Recommended dilution: 50-100 Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P100241-WB-1-P IHC PIC Description Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue or FADD antigen-treated (Neutralization experiment) using P100241(FADD Antibody) at dilution 1/35
