Fluorogenic Elastase Trypsin Substrate Catalog number: B2011430 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 2.5 mg Molecular Weight or Concentration: 1053.1 g/mol Supplied as: Lyophilized Applications: molecular tool for various biochemical applications Storage: -20 °C Keywords: Elastase/Trypsin Substrate, fluorogenic, (Z-AR)2Rh110 Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Al-Abdullah IH, Bagramyan K, Bilbao S, Qi M, Kalkum M. Fluorogenic Peptide Substrate for Quantification of Bacterial Enzyme Activities Sci Rep. 2017 Mar 13;7:44321. De Bruyn M, Ceuleers H, Hanning N, Berg M, De Man JG, Hulpiau P, Hermans C, Stenman UH, Koistinen H, Lambeir AM, De Winter BY, De Meester I. Proteolytic Cleavage of Bioactive Peptides and Protease-Activated Receptors in Acute and Post-Colitis Int J Mol Sci. 2021 Oct 2;22(19):10711. Sebzda T, Gnus J, Dziadkowiec B, Latka M, Gburek J. Diagnostic usefulness of selected proteases and acute phase factors in patients with colorectal adenocarcinoma World J Gastroenterol. 2021 Oct 21;27(39):6673-6688. Zimmerman M, Ashe B, Yurewicz EC, Patel G. Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substrates Anal Biochem. 1977 Mar;78(1):47-51. Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7754-9. Cheng L, Zhao Q. Aptamer-capture based assays for human neutrophil elastase Talanta. 2013 Mar 15;106:315-20. Hanning N, De Bruyn M, Ceuleers H, Boogaerts T, Berg M, Smet A, De Schepper HU, Joossens J, van Nuijs ALN, De Man JG, Augustyns K, De Meester I, De Winter BY. Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats Pharmaceutics. 2021 May 29;13(6):811. Kuromizu K, Shimokawa Y, Abe O, Izumiya N. New fluorogenic substrate for esterase activity of alpha-chymotrypsin and related enzymes Anal Biochem. 1985 Dec;151(2):534-9. Schick V, Scheiber JA, Mooren FC, Turi S, Ceyhan GO, Schnekenburger J, Sendler M, Schwaiger T, Omercevic A, Brandt Cv, Fluhr G, Domschke W, Krüger B, Mayerle J, Lerch MM. Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis Gut. 2014 Sep;63(9):1469-80.
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