The bark from Magnolia (Magnolia officinalis) has been used for over 1,000 years in the Traditional Medicinal systems of China and Japan, and was revered as a plant that replenishes Chi, the essence of life. Magnolia is a profound herb with a broad range of therapeutic actions, which supports its use in a vast number of chronic and metabolic diseases. While Magnolia’s historical use as an anxiolytic and antidepressant continues to be relevant today, recent research has also demonstrated that it may possess anticancer, antiatherosclerotic, cardioprotective, antiobesity, and insulin-sensitising properties. Magnolia appears to act on several central nervous system receptors and neurotransmitter pathways, a combination of which may be responsible for Magnolia’s nervous system effects. Magnolia is a strong anxiolytic herb that is beneficial in the treatment of nervous system, endocrine system, cardiovascular system, gastrointestinal system, and mood and memory disorders, and is able to support and normalise these closely entwined body systems.