Description N1-Me-Pseudo UTP solution is one of the most commonly used modified nucleoside triphosphates. It is mostly used as the reaction substrate or coenzyme of enzymes, such as in vitro transcription, RNA amplification, siRNA synthesis, etc. The modified mRNA containing pseudouridine has better nuclease stability and translation characteristics and changes the innate immune receptor and in vitro transcription. The interaction of RNA has a wide range of applications in the field of therapy and diagnosis.This product is produced in accordance with GMP process requirements and provided in liquid form. Feature Validated, product-specific processes and analytical methods Product-specific stability Documentation follows applicable GMP guidelines AOF production process and raw materials (TSE & BSE) Nitrosamine statement Regulatory support documents available Large-scale production The increased IVT yield and the decreased dsRNA content under the optimized Tris NTP reaction system Application RNA synthesis and amplification Building block for in vitro transcription Specification CAS No. 1428903-59-6 (free acid) Molecular formula C10H17N2O15P3 (free acid) Molecular weight 498.17 g/moL (free acid) Purity ≥ 99% Content 100mM ± 3mM Structure Component Components No. Name 10657ES70 10657ES80 10657 N1-Me-Pseudo UTP Tris Solution GMP-grade (100 mM) 100 μL 1 mL Storage The product should be stored at -25℃ ~ -15℃ for two years. Figures Increased the IVT yield Figure 1. The IVT yield was significantly increased under the optimized Tris NTP reaction system, compared with the sodium NTP reaction system. Decreased the dsRNA content Figure 2. The content of dsRNA was significantly decreased under the optimized Tris NTP reaction system, compared with the sodium NTP reaction system. The content of dsRNA was detected by the Dot Blot method. Documents: Manuals 10657_Manual_HB230112_EN.pdf
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