Oestrogen receptor blocker for men and women. Cruciferous acts as an aromatase (an enzyme that synthesizes oestrogen) inhibitor. Aromatase inhibitors block the synthesis of oestrogen. Indole-3-carbinol (I3C) (Brassica oleracea var. italica) Most ageing people (both men and women) are in oestrogen overload. With the dangers associated with excess oestrogen, Indole-3-carbinol (I3C) acts like an oestrogen vacuum cleaner. The process begins when I3C is ingested. Stomach acid converts it into a variety of products that ultimately induce the enzyme cytochrome P450, which signals the body to metabolize oestrogen via the 2-hydroxylation pathway. By funnelling oestrogen into this pathway, I3C essentially 'vacuums' away the oestrogen (Michnovic & Bradlow, 1991). Specific extracts from cruciferous vegetables (e.g. broccoli, cauliflower, Brussel sprouts) have been identified that modulate hormones in a way to help maintain healthy cell division. Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging oestrogen called 4-hydroxyestrone (Parkin & Malejka-Giganti, 2004). In addition, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates oestrogen hormones by favourably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone (Horn et a., 2002). Indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize oestrogen metabolites and xenobiotic oestrogen-like environmental chemicals (Nho & Jeffery, 2001). Human studies support the beneficial role of I3C in positively altering oestrogen metabolism. Di-Indoly Methane (DIM) Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging oestrogen called 4-hydroxyestrone (Parkin & Malejka-Giganti, 2004). In humans, Di-Indoly-methane (DIM) is derived from the ingestion of cruciferous vegetables. It is the stable, bioavailable form of indole-3-carbinol (I3C), but with 10 times the potency of I3C. Indications High oestrogen in men or women. Dose: As prescribed by your healthcare professional. Ingredients: Brassica oleracea var. italica - Super Concentrate Extract (plants and sprouts) (std. to 4% glucosinolates) Nasturtium officinale Extract (leaf) Uncaria tomentosa Extract (bark) (std. to 8% carboxy alkyl esters) Warnings: May interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product. Do not use if taking antacids, H2-receptor blockers (e.g. Zantac ), or proton-pump inhibitors (e.g. Nexium), as these drugs may impede the conversion of I3C to active metabolites. Prescription only. Only to be used under the supervision of your healthcare professional.
