Controls Urinary Incontinence in Dogs with PROIN Tablets Product Description PROIN Chewable Tablets for Dogs are a veterinary prescription medication used to help control urinary incontinence caused by urethral sphincter hypotonus. The tablets contain phenylpropanolamine hydrochloride, an alpha-adrenergic agent that helps increase urethral muscle tone and improve bladder control. These flavored chewable tablets are designed for oral administration and may help reduce urinary accidents when used according to veterinary guidance. *Signature Is Required Upon Delivery In The Following States: Arkansas, Illinois, Iowa, Louisiana, Oregon, West Virginia Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference. Benefits Supports Bladder Control: Helps manage urinary incontinence in dogs by increasing urethral sphincter tone and improving urinary retention. Clinically Proven Effectiveness: Clinical studies showed a reduction in weekly urinary accidents when dogs received recommended PROIN dosing. Veterinarian Prescribed Therapy: Approved for use under veterinary supervision to manage urinary incontinence due to urethral sphincter hypotonus. Convenient Oral Tablets: Scored chewable tablets allow dosing adjustments based on body weight in half-tablet increments. Flavored Chewable Form: Tablets are flavored and many dogs voluntarily consume doses, improving ease of administration for pet owners. Variants 25 mg Chewable Tablets 50 mg Chewable Tablets 75 mg Chewable Tablets Ingredients Active Ingredient Phenylpropanolamine Hydrochloride How to Use Recommended-Dosage Chart Dog Body Weight Recommended Dosage All body weights 2 mg/kg (0.91 mg/lb) body weight administered orally twice daily Dosage & Administration Instructions Veterinary Prescription Only: This medication is restricted for use by or on the order of a licensed veterinarian. Weight Based Dosing: Administer PROIN orally at a total dose of 2 mg/kg body weight twice daily. Scored Tablet Use: Tablets are scored and dosing should be calculated using half tablet increments based on body weight. Missed Dose Guidance: In case of a missed dose, administer it when remembered unless the next scheduled dose is close. Avoid Double Dosing: Skip the missed dose safely. Never give an extra dose at the same time to cover the one that was missed. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Pre-existing Health Issues: Use with caution in dogs that have heart disease, high blood pressure, liver problems, kidney impairment, diabetes, or glaucoma. Medication Interaction Risk: Exercise caution when used with sympathomimetics, tricyclic antidepressants, or monoamine oxidase inhibitors. Anesthetic Interaction Risk: Use cautiously in dogs receiving halogenated gaseous anesthetics due to increased risk of cardiac arrhythmias. Masked Infection Signs: Incontinence caused by urinary tract infections may be masked during treatment with this medication. Limited Safety Data: Safety has not been evaluated in breeding dogs, pregnant dogs, or lactating female dogs. Possible Side Effects Digestive Disturbances: Some dogs may experience vomiting, diarrhea, anorexia, or hypersalivation during treatment with phenylpropanolamine. Behavior Changes: Agitation, anxiety, vocalization, lethargy, confusion, or behavioral changes have been reported in treated dogs. Blood Pressure Increase: Elevated blood pressure or hypertension has been observed in some dogs during clinical studies. Neurologic Symptoms: Tremors, seizures, ataxia, or nervousness have been reported in some post approval safety reports. Cardiovascular Effects: Tachycardia, bradycardia, arrhythmias, or panting may occur in some dogs receiving treatment. Storage Information Room Temperature Storage: Store tablets at controlled room temperature between 20°C - 25°C for proper product stability. Temperature Excursions Allowed: Short term storage excursions between 15°C and 40°C are permitted without affecting product quality. Secure Storage Area: Keep the medication out of pets’ reach by storing it in a protected and secure spot. Child Safety: Keep the product out of reach of children because it is not intended for human use. Shipping & Return We offer ground, express, priority, and international delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What is PROIN used for in dogs? Ans: PROIN Chewable Tablets are prescribed to control urinary incontinence in dogs caused by urethral sphincter hypotonus. The medication contains phenylpropanolamine hydrochloride, which helps increase urethral muscle tone and improve bladder control, reducing the frequency of urinary accidents when administered as directed by a veterinarian. Q2: How long does PROIN take to start working in dogs? Ans: Phenylpropanolamine, the active ingredient in PROIN, is rapidly absorbed after oral administration. In humans the onset of action occurs within about 15 to 30 minutes, and improvement in urinary incontinence in dogs may occur after several days of consistent treatment. Q3: What is the recommended dosage of PROIN for dogs? Ans: The recommended oral dosage of PROIN for dogs is 2 mg per kilogram of body weight, which equals approximately 0.91 mg per pound. This dose is administered twice daily, and tablets are scored to allow accurate dosing in half-tablet increments when needed. Q4: Are there any side effects associated with PROIN for dogs? Ans: Some dogs may experience side effects such as vomiting, hypertension, loss of appetite, weight loss, behavioral changes, diarrhea, or lethargy. These reactions were reported during clinical studies and post approval safety monitoring of dogs receiving phenylpropanolamine treatment. Q5: Can PROIN be used in pregnant or breeding dogs? Ans: The safety of PROIN has not been evaluated in dogs used for breeding, pregnant dogs, or lactating females. Because of this limited safety information, veterinarians should be consulted before administering the medication to dogs in these categories.
