Revolt Topical Solution for Dogs 85.1-130 lbs (Plum Box)

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Monthly Heartworm and Parasite Prevention Spot-On for Extra-Large Dogs Product Description Revolt (Selamectin) Topical Solution for Dogs 85.1-130 lbs (Plum Box) is an FDA-approved prescription spot-on for extra-large dogs and puppies 6 weeks and older. Each plum-box tube delivers 3.0 mL of 120 mg/mL selamectin, providing 360 mg per application. Applied monthly at the base of the neck, it prevents heartworm, kills adult fleas, stops flea egg hatching, treats ear mites and sarcoptic mange, and controls American dog ticks. Made and packed in the USA. NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medicationsdogs and puppies can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial. Benefits Heartworm Disease Prevention: Applied monthly, Revolt clears infective D. immitis larvae picked up in the past 30 days before they progress into adult worms. Fast Flea Kill: Over 98% of adult fleas were killed within 36 hours in lab studies; monthly use achieved over 90% flea control within 30 days of the first dose. Ear Mite Control: Clears ear mite infestations with one monthly dose; a second dose may be needed in some dogs, and regular monthly use stops re-infestations. Sarcoptic Mange Treatment: About 50% of dogs saw itch relief after the first dose and around 90% after a second monthly treatment for sarcoptic mange. Tick Control: Controls American dog tick infestations monthly; in heavy infestations, an extra dose 14 days after the first may be needed before resuming monthly dosing. Waterfast After 2 Hours: Bathing or shampooing 2 or more hours after applying does not lower effectiveness against fleas or heartworm, great for active working breeds. Full-Size Tube: The 3.0 mL plum-box tube delivers the exact 360 mg selamectin dose for dogs 85.1-130 lbs without needing to combine smaller tubes. Ingredients Active Ingredients Selamectin: 360 mg per tube (120 mg/mL, 3.0 mL) for dogs 85.1-130 lbs Inactive Ingredients Isopropyl alcohol, butylated hydroxytoluene (BHT) How to Use Directions for Use Prescription Required: Revolt is federally restricted and must only be used under a licensed veterinarian's order with a valid prescription obtained first. Plum Box Dose: Apply the full 3.0 mL of one plum-box tube monthly; dogs over 130 lbs need the right tube combination to reach the 2.7 mg/lb minimum dose. Opening the Tube: Keep the tube pointing up and turn the cap until it snaps to break the seal; no need to fully remove it before use. Apply to Skin: Separate the coat at the back of the neck until skin is visible, then give the tube 3 to 4 firm presses in the same spot until nothing is left inside. Prevent Drawback: Keep the tube pressed on the last squeeze, drag it away from the liquid, then lift it off to stop any solution from being pulled back in. Do Not Massage: Leave the solution on the skin as applied; rubbing or massaging it in can affect how it spreads and how well it works. Avoid Damaged Skin: Never apply to a wet coat or broken skin; the isopropyl alcohol in the formula can cause real discomfort on damaged or raw tissue. Bathing Window: Wait at least 2 hours after applying before bathing or swimming; washing after that window will not reduce effectiveness against fleas or heartworm. Consistent Monthly Dosing: Apply monthly year-round or start within one month of first mosquito exposure and continue one month past the last seasonal exposure. Missed Dose: Apply the dose right away if one was missed, get back on the monthly schedule, and contact your vet to discuss whether further evaluation is needed. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Pre-Treatment Heartworm Test: Test extra-large dogs for heartworm before starting Revolt; infected dogs may need treatment to clear adult worms at the vet's direction first. No Adult Heartworm Action: Revolt only targets larvae and cannot eliminate established adult D. immitis; microfilariae counts may drop but Revolt is not approved for that use. Not for Sick Dogs: Do not use on sick, weak, or underweight dogs regardless of weight; always confirm the dog is in good health before starting monthly treatment. Flammable Product: This tube contains isopropyl alcohol and is highly flammable; keep well away from heat, sparks, flames, and ignition sources at all times. Unknown Heartworm History: Dogs with unknown heartworm histories testing negative may have pre-patent infections; retest 3 to 4 months after starting Revolt to confirm. Human Safety Precautions: Not for human use; wash hands after applying, keep away from eyes, and flush with water for 5 to 10 minutes if eye contact occurs. Possible Side Effects Temporary Site Reactions: Brief hair loss with or without inflammation at the treated spot is the most common reaction; clumped fur or a powdery residue may appear but clears up on its own. Lethargy and Vomiting: Tiredness and vomiting are the most frequently reported post-approval reactions in dogs following selamectin application and are generally mild. Gastrointestinal and Skin Reactions: Loose stools, reduced appetite, drooling, itching, and skin irritation have been reported after use; contact your vet if any of these do not clear up. Neurological Signs: Tremors, unsteady movement, and seizures have been reported in rare post-approval cases; get veterinary help right away if any of these appear. Storage Information Store Below 30°C: Keep the plum-box tube below 30°C (86°F) and away from heat, flames, sparks, and direct sunlight at all times as the product is flammable. Keep Out of Reach: Store in a locked, secure spot away from children and all animals; accidental ingestion of the 360 mg tube could cause serious harm to a pet or child. Shipping & Return We offer ground, express, and priority delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What does Revolt selamectin spot-on protect extra-large dogs from? Ans: Revolt Plum Box for dogs 85.1-130 lbs prevents heartworm (Dirofilaria immitis), kills adult fleas and stops flea eggs from hatching, clears ear mites (Otodectes cynotis) and sarcoptic mange (Sarcoptes scabiei), and controls American dog tick (Dermacentor variabilis) infestations with one monthly spot-on application at the base of the neck. Q2: How does Revolt Plum Box differ from the smaller Revolt tube sizes for dogs? Ans: The plum-box tube holds 3.0 mL with 360 mg selamectin, the largest single-tube dose in the Revolt range. All sizes share the same active ingredient and cover the same five conditions; the only difference between them is the volume and selamectin amount needed to hit the 2.7 mg/lb minimum dose for each weight group. Q3: Is Revolt topical solution the same as Revolution for extra-large dogs? Ans: Yes. Revolt (Aurora Pharmaceutical) contains selamectin at 120 mg/mL with 360 mg per tube, matching Revolution (Zoetis) for this weight class. Revolt is an FDA-approved generic that covers the same parasites in extra-large breeds and is manufactured and packed in the USA just like the original. Q4: Is Revolt selamectin topical safe for avermectin-sensitive Collie breeds in the extra-large weight range? Ans: In safety studies with avermectin-sensitive Collies at up to 5X the recommended dose, no selamectin-specific reactions were noted beyond drooling seen across all groups. Revolt has been tested safe in over 100 breeds, but always check with your vet about any breed-specific sensitivities before starting a monthly parasite preventative. Q5: What should I do if my extra-large dog misses a monthly Revolt heartworm prevention dose? Ans: Apply the missed dose right away and continue the regular monthly schedule from that point. Let your vet know a dose was skipped, especially if the gap went past 2 months during peak mosquito season, as that window raises the risk of heartworm infection and may need further evaluation. Clinical Research DailyMed – Official FDA Label for Selamectin (Revolt) VCA Animal Hospitals – Heartworm Prevention in Dogs Show more