SATB2 Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS65709-50, BS65709-100 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Swiss-Prot: Q9UPW6 Host: Rabbit Reactivity: Human, Mouse, Rat,Cow, Horse, Sheep, Applications: FCM All Applications: Flow-Cyt=1ug/test Background: SATB2 is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation. Purification and Purity: affinity purified by Protein A Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: SATB2 Polyclonal Antibody detects endogenous levels of SATB2 protein. Bioworld Molecular Weight: 83kDa Note: For research use only, not for use in diagnostic procedure. Alternative Name: DNA binding protein SATB2; DNA-binding protein SATB2; FLJ21474; FLJ32076; KIAA1034; MGC119474; MGC119477; SATB family member 2; SATB homeobox 2; SATB2; SATB2_HUMAN; Special AT rich sequence binding protein 2; Special AT-rich sequence-binding protein 2. Immunogen: KLH conjugated synthetic peptide derived from human SATB2:451-485/733 Conjugate: Unconjugated Modification: Unmodified
