Thorne Methyl-Guard Plus Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation* Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.* Various conditions and stressors can have an adverse impact on the body’s methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. In addition, approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally. Thorne’s Methyl-Guard Plus features betaine (trimethylgycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), as well as the active forms of vitamins B2 and B6, for providing efficient nutritional support for the body’s methylation challenges.* Benefits of Thorne’s Methyl-Guard Plus: Nutritional support for individuals who have MTHFR gene mutations* Enhanced cellular energy production fights fatigue* Helps maintain a healthy homocysteine level in the blood, which supports cardiovascular, cognitive, and bone health* Promotes fat metabolism and lean body composition* Supports neurotransmitter production – natural chemicals that play an important role in nervous system functions, like attention, focus, mood, and sleep* Promotes liver detoxification of many substances, including hormones like estrogen* Who can benefit from Methyl-Guard Plus: Individuals with mutations to MTHFR and other genes that adversely affect methylation* Aging individuals wanting to support their cardiovascular, cognitive, and metabolic health* Women seeking support for estrogen metabolism and bone health* Individuals wanting nutritional support for fat metabolism and maintenance of a healthy body composition* Anyone with limited consumption of methylation-supportive foods like green leafy vegetables, legumes, and cruciferous vegetables Why is methylation important: Methylation is a simple reaction where a small molecule known as a “methyl group” is transferred from one substance to another. Methylation significantly impacts many biochemical reactions in the body and plays a beneficial role in: Cardiovascular health Cellular energy production Fat metabolism Neurological function DNA production Liver detoxification processes Eye health Histamine balance Key Ingredients Betaine Anhydrous 5-MTHF Vitamin B Ingredient Amounts Serving Size: 3 Capsules Servings Per Container: 30 Warnings ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY If pregnant, consult your health professional before using this product. INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.